Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/37101
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dc.contributor.authorMioso, Robertoen_US
dc.contributor.authorToledo-Marante, Francisco J.en_US
dc.contributor.authorDe Souza Bezerra, Ranilsonen_US
dc.contributor.authorPereira Borges, Flavio Valadaresen_US
dc.contributor.authorDe Oliveira Santos, Barbara V.en_US
dc.contributor.authorHerrera Bravo de Laguna, Irmaen_US
dc.date.accessioned2018-05-17T10:47:13Z-
dc.date.available2018-05-17T10:47:13Z-
dc.date.issued2017en_US
dc.identifier.issn1420-3049en_US
dc.identifier.urihttp://hdl.handle.net/10553/37101-
dc.description.abstractThis extensive review covers research published between 2010 and 2012 regarding new compounds derived from marine sponges, including 62 species from 60 genera belonging to 33 families and 13 orders of the Demospongia class (Porifera). The emphasis is on the cytotoxic activity that bioactive metabolites from sponges may have on cancer cell lines. At least 197 novel chemical structures from 337 compounds isolated have been found to support this work. Details on the source and taxonomy of the sponges, their geographical occurrence, and a range of chemical structures are presented. The compounds discovered from the reviewed marine sponges fall into mainly four chemical classes: terpenoids (41.9%), alkaloids (26.2%), macrolides (8.9%) and peptides (6.3%) which, along with polyketides, sterols, and others show a range of biological activities. The key sponge orders studied in the reviewed research were Dictyoceratida, Haplosclerida, Tetractinellida, Poecilosclerida, and Agelasida. Petrosia, Haliclona (Haplosclerida), Rhabdastrella (Tetractinellida), Coscinoderma and Hyppospongia (Dictyioceratida), were found to be the most promising genera because of their capacity for producing new bioactive compounds. Several of the new compounds and their synthetic analogues have shown in vitro cytotoxic and pro-apoptotic activities against various tumor/cancer cell lines, and some of them will undergo further in vivo evaluation.en_US
dc.languageengen_US
dc.relation.ispartofMoleculesen_US
dc.sourceMolecules,v. 22 (208)en_US
dc.subject2401 Biología animal (zoología)en_US
dc.subject3209 Farmacologíaen_US
dc.subject.otherPoriferaen_US
dc.subject.otherMarine spongesen_US
dc.subject.otherPharmacologyen_US
dc.subject.otherBioactive moleculesen_US
dc.subject.otherCytotoxicityen_US
dc.subject.otherCancer cell linesen_US
dc.titleCytotoxic compounds derived from marine sponges. A Review (2010-2012)en_US
dc.typeinfo:eu-repo/semantics/reviewen_US
dc.typeinfo:eu-repo/semantics/reviewes
dc.typeArticlees
dc.identifier.doi10.3390/molecules22020208
dc.identifier.scopus85014045436
dc.identifier.isi000395552400022-
dc.contributor.authorscopusid55535031500
dc.contributor.authorscopusid56196675400
dc.contributor.authorscopusid7003699879
dc.contributor.authorscopusid57190220882
dc.contributor.authorscopusid7006476949
dc.contributor.authorscopusid14069914200
dc.identifier.issue2-
dc.relation.volume22-
dc.investigacionCienciasen_US
dc.type2Reseñaen_US
dc.contributor.daisngid2546418
dc.contributor.daisngid1695766
dc.contributor.daisngid19819062
dc.contributor.daisngid7891366
dc.contributor.daisngid6854191
dc.contributor.daisngid3019866
dc.contributor.wosstandardWOS:Mioso, R
dc.contributor.wosstandardWOS:Marante, FJT
dc.contributor.wosstandardWOS:Bezerra, RD
dc.contributor.wosstandardWOS:Borges, FVP
dc.contributor.wosstandardWOS:Santos, BVD
dc.contributor.wosstandardWOS:de Laguna, IHB
dc.date.coverdateFebrero 2017
dc.identifier.ulpgces
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.orcid0000-0003-1369-2037-
crisitem.author.orcid0000-0002-7842-591X-
crisitem.author.fullNameMioso, Roberto-
crisitem.author.fullNameToledo Marante, Francisco Javier-
crisitem.author.fullNameHerrera Bravo De Laguna, Irma-
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