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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/24028
DC FieldValueLanguage
dc.contributor.authorJulve Parreño, J.M.en_US
dc.contributor.authorHuet, E.en_US
dc.contributor.authorFernández-del-Carmen, A.en_US
dc.contributor.authorSegura, A.en_US
dc.contributor.authorVenturi, M.en_US
dc.contributor.authorGandía, A.en_US
dc.contributor.authorPan, W.-Sen_US
dc.contributor.authorAlbaladejo, I.en_US
dc.contributor.authorForment, J.en_US
dc.contributor.authorPla, D.en_US
dc.contributor.authorWigdorovitz, A.en_US
dc.contributor.authorCalvete, J.J.en_US
dc.contributor.authorGutiérrez Cabrera, Carlos Javieren_US
dc.contributor.authorGutiérrez, J.M.en_US
dc.contributor.authorGranell, A.en_US
dc.contributor.authorOrzáez, D.en_US
dc.date.accessioned2017-10-19T02:31:29Z-
dc.date.accessioned2018-03-08T13:06:36Z-
dc.date.available2017-10-19T02:31:29Z-
dc.date.available2018-03-08T13:06:36Z-
dc.date.issued2017en_US
dc.identifier.issn1467-7644en_US
dc.identifier.urihttp://hdl.handle.net/10553/24028-
dc.description.abstractAntivenoms developed from the plasma of hyperimmunized animals are the only effective treatment available against snakebite envenomation but shortage of supply contributes to the high morbidity and mortality toll of this tropical disease. We describe a synthetic biology approach to affordable and cost-effective antivenom production based on plant-made recombinant polyclonal antibodies (termed pluribodies). The strategy takes advantage of virus superinfection exclusion to induce the formation of somatic expression mosaics in agroinfiltrated plants, which enables the expression of complex antibody repertoires in a highly reproducible manner.en_US
dc.formatapplication/pdfes
dc.languageengen_US
dc.relationMINECO and ERDF (project grants IPT2011-0720-010000, BIO2013-42193-R and BIO2016-78601-R)en_US
dc.relationgrant BFU2013-42833-P from the Spanish Ministry of Economy and Competitivenessen_US
dc.relation.ispartofPlant Biotechnology Journalen_US
dc.rightsby-nc-ndes
dc.sourcePlant Biotechnology Journal [ISSN 1467-7644], v. 16(3), p. 727-736en_US
dc.subject3109 Ciencias veterinariasen_US
dc.subject3108 Fitopatologíaen_US
dc.subject.otherRecombinant polyclonal antibodiesen_US
dc.subject.otherMolecular pharmingen_US
dc.subject.otherSnake antivenomsen_US
dc.titleA synthetic biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxinsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/pbi.12823en_US
dc.identifier.scopus85030123782-
dc.identifier.isi000425452300003-
dc.contributor.authorscopusid57195922263-
dc.contributor.authorscopusid57195919101-
dc.contributor.authorscopusid22134178400-
dc.contributor.authorscopusid8851696200-
dc.contributor.authorscopusid57195923199-
dc.contributor.authorscopusid55585946300-
dc.contributor.authorscopusid57195920119-
dc.contributor.authorscopusid57200634443-
dc.contributor.authorscopusid6507618274-
dc.contributor.authorscopusid23025743900-
dc.contributor.authorscopusid6602679344-
dc.contributor.authorscopusid26643263500-
dc.contributor.authorscopusid7202545218-
dc.contributor.authorscopusid34975051900-
dc.contributor.authorscopusid6603864813-
dc.contributor.authorscopusid6507384919-
dc.identifier.crisid-;-;-;-;-;-;-;-;-;-;-;-;1327;-;-;--
dc.investigacionCienciasen_US
dc.project.referenceIPT-2011-0720-010000;BIO2013-42193-R;BIO2016-78601-R;IBFU2013-42833-Pes
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.type2Artículoen_US
dc.contributor.daisngid1605515-
dc.contributor.daisngid18330846-
dc.contributor.daisngid3837554-
dc.contributor.daisngid616701-
dc.contributor.daisngid14241642-
dc.contributor.daisngid12379558-
dc.contributor.daisngid2684555-
dc.contributor.daisngid7270799-
dc.contributor.daisngid1228044-
dc.contributor.daisngid1055940-
dc.contributor.daisngid778010-
dc.contributor.daisngid31412-
dc.contributor.daisngid475608-
dc.contributor.daisngid9990-
dc.contributor.daisngid226869-
dc.contributor.daisngid844944-
dc.identifier.external-;-;-;-;-;-;-;-;-;-;-;-;1327;-;-;--
dc.identifier.externalWOS:000425452300003-
dc.utils.revisionSíen_US
dc.contributor.wosstandardWOS:Parreno, JMJ-
dc.contributor.wosstandardWOS:Huet, E-
dc.contributor.wosstandardWOS:Fernandez-del-Carmen, A-
dc.contributor.wosstandardWOS:Segura, A-
dc.contributor.wosstandardWOS:Venturi, M-
dc.contributor.wosstandardWOS:Gandia, A-
dc.contributor.wosstandardWOS:Pan, WS-
dc.contributor.wosstandardWOS:Albaladejo, I-
dc.contributor.wosstandardWOS:Forment, J-
dc.contributor.wosstandardWOS:Pla, D-
dc.contributor.wosstandardWOS:Wigdorovitz, A-
dc.contributor.wosstandardWOS:Calvete, JJ-
dc.contributor.wosstandardWOS:Gutierrez, C-
dc.contributor.wosstandardWOS:Gutierrez, JM-
dc.contributor.wosstandardWOS:Granell, A-
dc.contributor.wosstandardWOS:Orzaez, D-
dc.date.coverdateMarzo 2018en_US
dc.identifier.supplement-;-;-;-;-;-;-;-;-;-;-;-;1327;-;-;--
dc.identifier.supplement-;-;-;-;-;-;-;-;-;-;-;-;1327;-;-;--
dc.identifier.supplement-;-;-;-;-;-;-;-;-;-;-;-;1327;-;-;--
dc.identifier.supplement-;-;-;-;-;-;-;-;-;-;-;-;1327;-;-;--
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-BASen_US
dc.description.sjr2,891
dc.description.jcr6,305
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Medicina Veterinaria e Investigación Terapéutica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0003-0764-7408-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameGutiérrez Cabrera,Carlos Javier-
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