Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/24028
Title: A synthetic biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxins
Authors: Julve Parreño, J.M.
Huet, E.
Fernández-del-Carmen, A.
Segura, A.
Venturi, M.
Gandía, A.
Pan, W.-S
Albaladejo, I.
Forment, J.
Pla, D.
Wigdorovitz, A.
Calvete, J.J.
Gutiérrez Cabrera, Carlos 
Gutiérrez, J.M.
Granell, A.
Orzáez, D.
UNESCO Clasification: 3109 Ciencias veterinarias
3108 Fitopatología
Keywords: Recombinant polyclonal antibodies
Molecular pharming
Snake antivenoms
Issue Date: 2017
Journal: Plant Biotechnology Journal 
Abstract: Antivenoms developed from the plasma of hyperimmunized animals are the only effective treatment available against snakebite envenomation but shortage of supply contributes to the high morbidity and mortality toll of this tropical disease. We describe a synthetic biology approach to affordable and cost-effective antivenom production based on plant-made recombinant polyclonal antibodies (termed pluribodies). The strategy takes advantage of virus superinfection exclusion to induce the formation of somatic expression mosaics in agroinfiltrated plants, which enables the expression of complex antibody repertoires in a highly reproducible manner.
URI: http://hdl.handle.net/10553/24028
ISSN: 1467-7644
DOI: 10.1111/pbi.12823
Source: Plant Biotechnology Journal [ISSN 1467-7644], p. 1-10
Rights: by-nc-nd
Appears in Collections:Artículos
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