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http://hdl.handle.net/10553/24028
| Título: | A synthetic biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxins | Autores/as: | Julve Parreño, J.M. Huet, E. Fernández-del-Carmen, A. Segura, A. Venturi, M. Gandía, A. Pan, W.-S Albaladejo, I. Forment, J. Pla, D. Wigdorovitz, A. Calvete, J.J. Gutiérrez Cabrera, Carlos Javier Gutiérrez, J.M. Granell, A. Orzáez, D. |
Clasificación UNESCO: | 3109 Ciencias veterinarias 3108 Fitopatología |
Palabras clave: | Recombinant polyclonal antibodies Molecular pharming Snake antivenoms |
Fecha de publicación: | 2017 | Proyectos: | MINECO and ERDF (project grants IPT2011-0720-010000, BIO2013-42193-R and BIO2016-78601-R) grant BFU2013-42833-P from the Spanish Ministry of Economy and Competitiveness |
Publicación seriada: | Plant Biotechnology Journal | Resumen: | Antivenoms developed from the plasma of hyperimmunized animals are the only effective treatment available against snakebite envenomation but shortage of supply contributes to the high morbidity and mortality toll of this tropical disease. We describe a synthetic biology approach to affordable and cost-effective antivenom production based on plant-made recombinant polyclonal antibodies (termed pluribodies). The strategy takes advantage of virus superinfection exclusion to induce the formation of somatic expression mosaics in agroinfiltrated plants, which enables the expression of complex antibody repertoires in a highly reproducible manner. | URI: | http://hdl.handle.net/10553/24028 | ISSN: | 1467-7644 | DOI: | 10.1111/pbi.12823 | Fuente: | Plant Biotechnology Journal [ISSN 1467-7644], v. 16(3), p. 727-736 | Derechos: | by-nc-nd |
| Colección: | Artículos |
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