Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/24028
Título: A synthetic biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxins
Autores/as: Julve Parreño, J.M.
Huet, E.
Fernández-del-Carmen, A.
Segura, A.
Venturi, M.
Gandía, A.
Pan, W.-S
Albaladejo, I.
Forment, J.
Pla, D.
Wigdorovitz, A.
Calvete, J.J.
Gutiérrez Cabrera, Carlos Javier 
Gutiérrez, J.M.
Granell, A.
Orzáez, D.
Clasificación UNESCO: 3109 Ciencias veterinarias
3108 Fitopatología
Palabras clave: Recombinant polyclonal antibodies
Molecular pharming
Snake antivenoms
Fecha de publicación: 2017
Proyectos: MINECO and ERDF (project grants IPT2011-0720-010000, BIO2013-42193-R and BIO2016-78601-R)
grant BFU2013-42833-P from the Spanish Ministry of Economy and Competitiveness
Publicación seriada: Plant Biotechnology Journal 
Resumen: Antivenoms developed from the plasma of hyperimmunized animals are the only effective treatment available against snakebite envenomation but shortage of supply contributes to the high morbidity and mortality toll of this tropical disease. We describe a synthetic biology approach to affordable and cost-effective antivenom production based on plant-made recombinant polyclonal antibodies (termed pluribodies). The strategy takes advantage of virus superinfection exclusion to induce the formation of somatic expression mosaics in agroinfiltrated plants, which enables the expression of complex antibody repertoires in a highly reproducible manner.
URI: http://hdl.handle.net/10553/24028
ISSN: 1467-7644
DOI: 10.1111/pbi.12823
Fuente: Plant Biotechnology Journal [ISSN 1467-7644], v. 16(3), p. 727-736
Derechos: by-nc-nd
Colección:Artículos
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