Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/20867
Title: Possible mechanisms of host resistance to Haemonchus contortusinfection in sheep breeds native to the Canary Islands
Authors: Guo, Zhengyu
González, Jorge Francisco 
Hernández Vega, Julia Natividad 
McNeilly, Tom N.
Corripio-Miyar, Yolanda
Frew, David
Morrison, Tyler
Yu, Peng
Li, Robert W.
UNESCO Clasification: 310902 Genética
240108 Genética animal
Keywords: Quantitative Trait Loci
Gastrointestinal Nematodes
Parasite Resistance
Dorper Sheep
Red Maasai, et al
Issue Date: 2016
Journal: Scientific Reports 
Abstract: Haemonchus contortus appears to be the most economically important helminth parasite for small ruminant production in many regions of the world. The two sheep breeds native to the Canary Islands display distinctly different resistant phenotypes under both natural and experimental infections. Canaria Hair Breed (CHB) tends to have significantly lower worm burden and delayed and reduced egg production than the susceptible Canaria Sheep (CS). To understand molecular mechanisms underlying host resistance, we compared the abomasal mucosal transcriptome of the two breeds in response to Haemonchus infection using RNAseq technology. A broad range of mechanisms have evolved in resistant CHB to provide protection against the parasite. Our findings suggest that readily inducible acute inflammatory responses, complement activation, accelerated cell proliferation and subsequent tissue repair, and immunity directed against parasite fecundity all contributed to the development of host resistance to parasitic infection in the resistant breed.
URI: http://hdl.handle.net/10553/20867
ISSN: 2045-2322
DOI: 10.1038/srep26200
Source: Scientific Reports [ISSN 2045-2322], v. 6 (26200)
Rights: by-nc-nd
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