Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/20867
DC FieldValueLanguage
dc.contributor.authorGuo, Zhengyuen_US
dc.contributor.authorGonzález, Jorge Franciscoen_US
dc.contributor.authorHernández Vega, Julia Natividaden_US
dc.contributor.authorMcNeilly, Tom N.en_US
dc.contributor.authorCorripio-Miyar, Yolandaen_US
dc.contributor.authorFrew, Daviden_US
dc.contributor.authorMorrison, Tyleren_US
dc.contributor.authorYu, Pengen_US
dc.contributor.authorLi, Robert W.en_US
dc.date.accessioned2017-03-09T03:30:26Z-
dc.date.accessioned2018-03-16T09:14:04Z-
dc.date.available2017-03-09T03:30:26Z-
dc.date.available2018-03-16T09:14:04Z-
dc.date.issued2016en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://hdl.handle.net/10553/20867-
dc.description.abstractHaemonchus contortus appears to be the most economically important helminth parasite for small ruminant production in many regions of the world. The two sheep breeds native to the Canary Islands display distinctly different resistant phenotypes under both natural and experimental infections. Canaria Hair Breed (CHB) tends to have significantly lower worm burden and delayed and reduced egg production than the susceptible Canaria Sheep (CS). To understand molecular mechanisms underlying host resistance, we compared the abomasal mucosal transcriptome of the two breeds in response to Haemonchus infection using RNAseq technology. A broad range of mechanisms have evolved in resistant CHB to provide protection against the parasite. Our findings suggest that readily inducible acute inflammatory responses, complement activation, accelerated cell proliferation and subsequent tissue repair, and immunity directed against parasite fecundity all contributed to the development of host resistance to parasitic infection in the resistant breed.en_US
dc.formatapplication/pdf-
dc.languageengen_US
dc.relation.ispartofScientific Reportsen_US
dc.rightsby-nc-nd-
dc.sourceScientific Reports [ISSN 2045-2322], v. 6 (26200)en_US
dc.subject310902 Genéticaen_US
dc.subject240108 Genética animalen_US
dc.subject.otherQuantitative Trait Loci
dc.subject.otherGastrointestinal Nematodes
dc.subject.otherParasite Resistance
dc.subject.otherDorper Sheep
dc.subject.otherRed Maasai
dc.subject.otherAmphiregulin
dc.subject.otherIdentification
dc.subject.otherInflammation
dc.subject.otherHelminth
dc.subject.otherImmunity
dc.titlePossible mechanisms of host resistance to Haemonchus contortusinfection in sheep breeds native to the Canary Islandsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/srep26200
dc.identifier.scopus84970015771-
dc.identifier.isi000376554900001-
dc.contributor.authorscopusid56949480800-
dc.contributor.authorscopusid7404492965-
dc.contributor.authorscopusid57188977277-
dc.contributor.authorscopusid36978592100-
dc.contributor.authorscopusid14624902300-
dc.contributor.authorscopusid6603829629-
dc.contributor.authorscopusid57189390183-
dc.contributor.authorscopusid56849768100-
dc.contributor.authorscopusid8591086500-
dc.relation.volume6-
dc.investigacionCienciasen_US
dc.project.referenceAGL2009/09985-
dc.rights.accessrightsAcceso libre-
dc.type2Artículoen_US
dc.contributor.daisngid3135694
dc.contributor.daisngid1988579
dc.contributor.daisngid5685596
dc.contributor.daisngid170985
dc.contributor.daisngid2251711
dc.contributor.daisngid285998
dc.contributor.daisngid9667861
dc.contributor.daisngid2510611
dc.contributor.daisngid458707
dc.contributor.wosstandardWOS:Guo, ZY
dc.contributor.wosstandardWOS:Gonzalez, JF
dc.contributor.wosstandardWOS:Hernandez, JN
dc.contributor.wosstandardWOS:McNeilly, TN
dc.contributor.wosstandardWOS:Corripio-Miyar, Y
dc.contributor.wosstandardWOS:Frew, D
dc.contributor.wosstandardWOS:Morrison, T
dc.contributor.wosstandardWOS:Yu, P
dc.contributor.wosstandardWOS:Li, RW
dc.date.coverdateMayo 2016
dc.identifier.ulpgces
dc.description.sjr1,625
dc.description.jcr4,259
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0001-7374-9256-
crisitem.author.orcid0000-0002-3843-2509-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameGonzález Pérez, Jorge Francisco-
crisitem.author.fullNameHernández Vega, Julia Natividad-
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