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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/18969
Title: The Influence of Estrogens on the Biological and Therapeutic Actions of Growth Hormone in the Liver
Authors: Mirecki Garrido, Mercedes de 
Guerra, Borja 
Mateos-Díaz, Carlos
Jímenez-Monzón, Roberto
Diaz-Chico, Bonifacio 
Díaz-Chico, Juan C. 
Fernández-Pérez, Leandro 
UNESCO Clasification: 320101 Oncología
Keywords: growth hormone
17β-estradiol
liver
growth
metabolism
STAT5
Issue Date: 2012
Journal: Pharmaceuticals 
Abstract: GH is main regulator of body growth and composition, somatic development, intermediate metabolism and gender-dependent dimorphism in mammals. The liver is a direct target of estrogens because it expresses estrogen receptors which are connected with development, lipid metabolism and insulin sensitivity, hepatic carcinogenesis, protection from drug-induced toxicity and fertility. In addition, estrogens can modulate GH actions in liver by acting centrally, regulating pituitary GH secretion, and, peripherally, by modulating GHR-JAK2-STAT5 signalling pathway
GH is main regulator of body growth and composition, somatic development, intermediate metabolism and gender-dependent dimorphism in mammals. The liver is a direct target of estrogens because it expresses estrogen receptors which are connected with development, lipid metabolism and insulin sensitivity, hepatic carcinogenesis, protection from drug-induced toxicity and fertility. In addition, estrogens can modulate GH actions in liver by acting centrally, regulating pituitary GH secretion, and, peripherally, by modulating GHR-JAK2-STAT5 signalling pathway
URI: http://hdl.handle.net/10553/18969
ISSN: 1424-8247
DOI: 10.3390/ph5070758
Source: Pharmaceuticals,v. 5, p. 758-778
Rights: by-nc-nd
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