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| Title: | The Influence of Estrogens on the Biological and Therapeutic Actions of Growth Hormone in the Liver | Authors: | Mirecki Garrido, Mercedes de Guerra, Borja Mateos-Díaz, Carlos Jímenez-Monzón, Roberto Diaz-Chico, Bonifacio Díaz-Chico, Juan C. Fernández-Pérez, Leandro |
UNESCO Clasification: | 320101 Oncología | Keywords: | growth hormone 17β-estradiol liver growth metabolism STAT5 |
Issue Date: | 2012 | Journal: | Pharmaceuticals | Abstract: | GH is main regulator of body growth and composition, somatic development, intermediate metabolism and gender-dependent dimorphism in mammals. The liver is a direct target of estrogens because it expresses estrogen receptors which are connected with development, lipid metabolism and insulin sensitivity, hepatic carcinogenesis, protection from drug-induced toxicity and fertility. In addition, estrogens can modulate GH actions in liver by acting centrally, regulating pituitary GH secretion, and, peripherally, by modulating GHR-JAK2-STAT5 signalling pathway GH is main regulator of body growth and composition, somatic development, intermediate metabolism and gender-dependent dimorphism in mammals. The liver is a direct target of estrogens because it expresses estrogen receptors which are connected with development, lipid metabolism and insulin sensitivity, hepatic carcinogenesis, protection from drug-induced toxicity and fertility. In addition, estrogens can modulate GH actions in liver by acting centrally, regulating pituitary GH secretion, and, peripherally, by modulating GHR-JAK2-STAT5 signalling pathway |
URI: | http://hdl.handle.net/10553/18969 | ISSN: | 1424-8247 | DOI: | 10.3390/ph5070758 | Source: | Pharmaceuticals,v. 5, p. 758-778 | Rights: | by-nc-nd |
| Appears in Collections: | Artículos |
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