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Title: 2-Hydroxyethyl methacrylate (2-HEMA) sensitization, a global epidemic at its peak in Spain?
Authors: Gatica-Ortega, Maria Elena
Pastor-Nieto, Maria Antonia
Giménez-Arnau, Ana María
Mercader-García, Pedro
Sanz-Sánchez, Tatiana
Carrascosa-Carrillo, José Manuel
Córdoba-Guijarro, Susana
Sánchez Pérez, Javier
Silvestre, Juan Francisco
Frutos, Francisco Javier Ortiz de
Tous-Romero, Fátima
Fernández-Redondo, Virginia
Serra-Baldrich, Esther
Ruíz-González, Inmaculada
González Pérez, Ricardo
Miquel-Miquel, Javier
Guillén, Paloma Sánchez Pedreño
Hervella-García, Marcos
Heras-Mendaza, Felipe
Gómez-de-la-Fuente, Enrique
Zaragoza-Ninet, Violeta
Gilo, Araceli Sánchez
Rodríguez-Serna, Mercedes
Melé-Ninot, Gemma
Descalzo, Miguel Ángel
de-Vega, Marina
García-Doval, Ignacio
Borrego Hernando, Leopoldo 
UNESCO Clasification: 32 Ciencias médicas
320106 Dermatología
Keywords: (Meth)Acrylates
2-Hydroxyethyl Methacrylate
Acrylic Nails
Allergic Contact Dermatitis, et al
Issue Date: 2024
Journal: Contact Dermatitis 
Abstract: Background: A global epidemic of allergic contact dermatitis to (meth)acrylates has been described in relation to the widespread use of manicure products. Objectives: To evaluate the frequency of sensitization to 2-hydroxyethyl methacrylate (2-HEMA) among consecutively patch tested patients with eczema in Spain; the percentage of current relevance; the MOAHLFA index; and, the potential sources of exposure to (meth)acrylates. Methods: From January 2019 to December 2022, 2-HEMA 2% pet. was prospectively patch tested in 24 REIDAC (Spanish Allergic Contact Dermatitis Registry) centres. Results: Six thousand one hundred thirty-four patients were consecutively patch tested with 2-HEMA 2% pet. 265/6134 (4.3%) were positive. Positive reactions of current relevance were identified to involve 184/265 (69%). The efficiency (number of patch tests needed to detect relevant positive patch test reactions) was 34 (6134/184). The variable ‘occupational’ was found to be significantly associated with a higher risk for relevant positive reactions to 2-HEMA (OR: 10.9; 95% CI: 8.1–14.9). Conclusion: (Meth)acrylate sensitization is a prevalent health issue in Spain. 2-HEMA 2% pet. has been identified to be a highly effective (meth)acrylate allergy marker in the GEIDAC baseline series. The responsible authorities should implement policies guaranteeing accurate labelling of industrial, medical, and consumer materials while ensuring the enforcement of said labelling through appropriate legal means.
ISSN: 0105-1873
DOI: 10.1111/cod.14520
Source: Contact Dermatitis[ISSN 0105-1873],p. 1-7 (Febrero 2024)
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