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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/128797
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dc.contributor.authorDe La Iglesia Íñigo, Silvia Narcisaen_US
dc.contributor.authorLópez Jorge, Carmen Elsaen_US
dc.contributor.authorGómez Casares, María Teresaen_US
dc.contributor.authorLemes Castellano, Angelinaen_US
dc.contributor.authorMartín Cabrera, Pedroen_US
dc.contributor.authorLópez Brito, Jezabelen_US
dc.contributor.authorSuárez Cabrera, Alexiaen_US
dc.contributor.authorMolero Labarta, María Teresaen_US
dc.date.accessioned2024-02-05T15:18:07Z-
dc.date.available2024-02-05T15:18:07Z-
dc.date.issued2009en_US
dc.identifier.issn0145-2126en_US
dc.identifier.urihttp://hdl.handle.net/10553/128797-
dc.description.abstractRenin-angiotensin system (RAS) in the bone marrow is related to proliferation and cellular differentiation. We investigated the effect of ACE inhibitors (ACEI) captopril (>1 mM) and trandolapril (>0.05 mM) and losartan (0.2 mM) on K562 cell line and K562 transfected with c-myc, bcl-x and bcl-2 (KmycB, Kbclx and Kbcl2 respectively). RAS components, proliferation, apoptosis and c-myc expression were analyzed. ACEI and losartan inhibited cell growth, decreased c-myc expression and increased apoptosis. These effects seem to be associated to angiotensin II-induced Smad activation. This work offers a new possible line of treatment for some acute myeloid leukemias and a new area of clinical research.en_US
dc.languageengen_US
dc.relation.ispartofLeukemia Researchen_US
dc.sourceLeukemia Research [0145-2126], v. 33(6), p. 810-816 (Junio 2009)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320708 Hematologíaen_US
dc.subject.otherRenin-angiotensin systemen_US
dc.subject.otherLeukemia cell linesen_US
dc.subject.otherK562en_US
dc.subject.otherHL60en_US
dc.subject.otherACE inhibitorsen_US
dc.titleInduction of apoptosis in leukemic cell lines treated with captopril, trandolapril and losartan: A new role in the treatment of leukaemia for these agentsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.leukres.2008.09.029en_US
dc.identifier.pmid19010543-
dc.identifier.scopus2-s2.0-63349098669-
dc.identifier.isiWOS:000265771600018-
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dc.description.lastpage816en_US
dc.identifier.issue6-
dc.description.firstpage810en_US
dc.relation.volume33en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages7en_US
dc.utils.revisionSíen_US
dc.date.coverdateJunio 2009en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr2,358
dc.description.jcrqQ3
dc.description.scieSCIE
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0003-1399-836X-
crisitem.author.orcid0000-0003-0505-5126-
crisitem.author.fullNameDe La Iglesia Íñigo, Silvia Narcisa-
crisitem.author.fullNameGómez Casares, María Teresa-
crisitem.author.fullNameMolero Labarta, María Teresa-
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