Induction of apoptosis in leukemic cell lines treated with captopril, trandolapril and losartan: A new role in the treatment of leukaemia for these agents

Título:	Induction of apoptosis in leukemic cell lines treated with captopril, trandolapril and losartan: A new role in the treatment of leukaemia for these agents
Autores/as:	De La Iglesia Íñigo, Silvia Narcisa López Jorge, Carmen Elsa Gómez Casares, María Teresa Lemes Castellano, Angelina Martín Cabrera, Pedro López Brito, Jezabel Suárez Cabrera, Alexia Molero Labarta, María Teresa
Clasificación UNESCO:	32 Ciencias médicas 320708 Hematología
Palabras clave:	Renin-angiotensin system Leukemia cell lines K562 HL60 ACE inhibitors
Fecha de publicación:	2009
Publicación seriada:	Leukemia Research
Resumen:	Renin-angiotensin system (RAS) in the bone marrow is related to proliferation and cellular differentiation. We investigated the effect of ACE inhibitors (ACEI) captopril (>1 mM) and trandolapril (>0.05 mM) and losartan (0.2 mM) on K562 cell line and K562 transfected with c-myc, bcl-x and bcl-2 (KmycB, Kbclx and Kbcl2 respectively). RAS components, proliferation, apoptosis and c-myc expression were analyzed. ACEI and losartan inhibited cell growth, decreased c-myc expression and increased apoptosis. These effects seem to be associated to angiotensin II-induced Smad activation. This work offers a new possible line of treatment for some acute myeloid leukemias and a new area of clinical research.
URI:	http://hdl.handle.net/10553/128797
ISSN:	0145-2126
DOI:	10.1016/j.leukres.2008.09.029
Fuente:	Leukemia Research [0145-2126], v. 33(6), p. 810-816 (Junio 2009)
Colección:	Artículos

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