Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/121492
Título: Host genetic variation explains reduced protection of commercial vaccines against Piscirickettsia salmonis in Atlantic salmon
Autores/as: Figueroa, C
Veloso, P
Espin, Lenin
Dixon, B
Torrealba, D
Said Elalfy,Islam 
Afonso López, Juan Manuel 
Soto, C
Conejeros, P
Gallardo, JA
Clasificación UNESCO: 310502 Piscicultura
310902 Genética
241210 Vacunas
Palabras clave: Ecological epidemiology
Heritable quantitative trait
Ichthyology
Fecha de publicación: 2020
Publicación seriada: Scientific Reports 
Resumen: Vaccination is a widely used control strategy to prevent Piscirickettsia salmonis causing disease in salmon farming. However, it is not known why all the currently available commercial vaccines generally fail to protect against this pathogenic bacteria. Here, we report, from two different populations, that between-family variation is a strong intrinsic factor that determines vaccine protection for this disease. While in some full-sib families, the protection added by vaccination increased the survival time in 13 days in comparison with their unvaccinated siblings; in other families, there was no added protection by vaccination or even it was slightly negative. Resistance to P. salmonis, measured as days to death, was higher in vaccinated than unvaccinated fish, but only a moderate positive genetic correlation was obtained between these traits. This disputes a previous hypothesis, that stated that both traits were fully controlled by the same genes, and challenges the use of unvaccinated fish as gold standard for evaluating and selecting fish resistant to P. salmonis, particularly if the offspring will be vaccinated. More studies are necessary to evaluate if variation in the host immune response to vaccination could explain the between-family differences in resistance observed in vaccinated fish.
URI: http://hdl.handle.net/10553/121492
ISSN: 2045-2322
DOI: 10.1038/s41598-020-70847-9
Fuente: Scientific Reports [ISSN 2045-2322], v. 10, 18252 (2020)
Colección:Artículos
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