Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/121492
Campo DC Valoridioma
dc.contributor.authorFigueroa, Cen_US
dc.contributor.authorVeloso, Pen_US
dc.contributor.authorEspin, Leninen_US
dc.contributor.authorDixon, Ben_US
dc.contributor.authorTorrealba, Den_US
dc.contributor.authorSaid Elalfy,Islamen_US
dc.contributor.authorAfonso López, Juan Manuelen_US
dc.contributor.authorSoto, Cen_US
dc.contributor.authorConejeros, Pen_US
dc.contributor.authorGallardo, JAen_US
dc.date.accessioned2023-03-22T13:49:50Z-
dc.date.available2023-03-22T13:49:50Z-
dc.date.issued2020en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://hdl.handle.net/10553/121492-
dc.description.abstractVaccination is a widely used control strategy to prevent Piscirickettsia salmonis causing disease in salmon farming. However, it is not known why all the currently available commercial vaccines generally fail to protect against this pathogenic bacteria. Here, we report, from two different populations, that between-family variation is a strong intrinsic factor that determines vaccine protection for this disease. While in some full-sib families, the protection added by vaccination increased the survival time in 13 days in comparison with their unvaccinated siblings; in other families, there was no added protection by vaccination or even it was slightly negative. Resistance to P. salmonis, measured as days to death, was higher in vaccinated than unvaccinated fish, but only a moderate positive genetic correlation was obtained between these traits. This disputes a previous hypothesis, that stated that both traits were fully controlled by the same genes, and challenges the use of unvaccinated fish as gold standard for evaluating and selecting fish resistant to P. salmonis, particularly if the offspring will be vaccinated. More studies are necessary to evaluate if variation in the host immune response to vaccination could explain the between-family differences in resistance observed in vaccinated fish.en_US
dc.languageengen_US
dc.relation.ispartofScientific Reportsen_US
dc.sourceScientific Reports [ISSN 2045-2322], v. 10, 18252 (2020)en_US
dc.subject310502 Pisciculturaen_US
dc.subject310902 Genéticaen_US
dc.subject241210 Vacunasen_US
dc.subject.otherEcological epidemiologyen_US
dc.subject.otherHeritable quantitative traiten_US
dc.subject.otherIchthyologyen_US
dc.titleHost genetic variation explains reduced protection of commercial vaccines against Piscirickettsia salmonis in Atlantic salmonen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-020-70847-9en_US
dc.identifier.pmid33106499-
dc.identifier.scopus2-s2.0-85092447022-
dc.identifier.isiWOS:000615370300007-
dc.contributor.orcid0000-0001-7103-4783-
dc.contributor.orcid0000-0001-6569-0741-
dc.contributor.orcid0000-0002-9774-4123-
dc.contributor.orcid0000-0003-4213-5483-
dc.contributor.orcid0000-0003-0807-4234-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid0000-0001-5073-7121-
dc.contributor.orcid0000-0002-7717-8726-
dc.identifier.issue1-
dc.relation.volume10en_US
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr1,24
dc.description.jcr4,379
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR Grupo de Investigación en Acuicultura-
crisitem.author.deptIU de Investigación en Acuicultura Sostenible y Ec-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.parentorgIU de Investigación en Acuicultura Sostenible y Ec-
crisitem.author.fullNameSaid Elalfy,Islam-
crisitem.author.fullNameAfonso López, Juan Manuel-
Colección:Artículos
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