Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/121019
DC FieldValueLanguage
dc.contributor.authorOtazo-Perez, Andreaen_US
dc.contributor.authorAsensio-Calavia, Patriciaen_US
dc.contributor.authorGonzalez-Acosta, Sergioen_US
dc.contributor.authorBaca-Gonzalez, Victoriaen_US
dc.contributor.authorLópez, Manuel R.en_US
dc.contributor.authorMorales De La Nuez, Antonio Joséen_US
dc.contributor.authorPérez de la Lastra, José Manuelen_US
dc.date.accessioned2023-03-10T10:16:11Z-
dc.date.available2023-03-10T10:16:11Z-
dc.date.issued2022en_US
dc.identifier.issn2076-393Xen_US
dc.identifier.urihttp://hdl.handle.net/10553/121019-
dc.description.abstractThe immune systems of all vertebrates contain cathelicidins, a family of antimicrobial peptides. Cathelicidins are a type of innate immune effector that have a number of biological functions, including a well-known direct antibacterial action and immunomodulatory function. In search of new templates for antimicrobial peptide discovery, we have identified and characterized the cathelicidin of the small mammal Talpa occidentalis. We describe the heterogeneity of cathelicidin in the order Eulipotyphla in relation to the Iberian mole and predict its antibacterial activity using bioinformatics tools. In an effort to correlate these findings, we derived the putative active peptide and performed in vitro hemolysis and antimicrobial activity assays, confirming that Iberian mole cathelicidins are antimicrobial. Our results showed that the Iberian mole putative peptide, named To-KL37 (KLFGKVGNLLQKGWQKIKNIGRRIKDFFRNIRPMQEA) has antibacterial and antifungal activity. Understanding the antimicrobial defense of insectivores may help scientists prevent the spread of pathogens to humans. We hope that this study can also provide new, effective antibacterial peptides for future drug development.en_US
dc.languageengen_US
dc.relation.ispartofVaccinesen_US
dc.sourceVaccines [ISSN 2076-393X], v.10 (7), 1105en_US
dc.subject310905 Microbiologíaen_US
dc.subject.otherEulipotyphlaen_US
dc.subject.otherInsectivoresen_US
dc.subject.otherMammalsen_US
dc.subject.otherInnate immunityen_US
dc.subject.otherAntimicrobial peptideen_US
dc.subject.otherTalpidaeen_US
dc.titleAntimicrobial Activity of Cathelicidin-Derived Peptide from the Iberian Mole Talpa occidentalisen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/vaccines10071105en_US
dc.identifier.scopus2-s2.0-85137299451-
dc.identifier.isiWOS:000833692800001-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid0000-0001-8413-8426-
dc.contributor.orcid0000-0002-6012-8255-
dc.contributor.orcid0000-0001-7195-7211-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid0000-0002-0184-2037-
dc.contributor.orcid0000-0003-4663-5565-
dc.identifier.issue7-
dc.relation.volume10en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.date.coverdateJulio 2022en_US
dc.identifier.ulpgcNoen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr1,655
dc.description.jcr7,8
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds10,4
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0002-0184-2037-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameMorales De La Nuez, Antonio José-
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