Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/118888
Título: A Common Variant at the 3'untranslated Region of the CCL7 Gene (rs17735770) Is Associated With Decreased Susceptibility to Coronary Heart Disease
Autores/as: Medina-Gil, José María
Pérez-García, Ana
Saavedra Santana, Pedro 
Díaz-Carrasco, Asunción
Martínez Quintana, Efrén 
Rodríguez-González, Fayna
Ramírez, Cristina M.
Riaño, Marta
Garay Sanchez, Paloma 
Tugores, Antonio 
Clasificación UNESCO: 32 Ciencias médicas
3205 Medicina interna
Palabras clave: Cardiovascular Disease
Ccl7
Chemokine
Genetics
Microrna (Mirna)
Fecha de publicación: 2022
Publicación seriada: Frontiers In Cardiovascular Medicine 
Resumen: Monocytes participate in the development of atherosclerosis through the action of cytokines and other inflammatory mediators. Among them, CCR2 and its ligands, CCL2 and CCL7 play an important role, so the main objective of this work was to determine whether genetic variants affecting their activity were associated with cardiovascular disease. A cohort of 519 patients that have suffered coronary events was analyzed under a propensity score-matching protocol selecting a homogeneous set of cases and controls, according to age, sex, smoking status, dyslipidemia, arterial hypertension and type 2 diabetes as risk factors. While dyslipidemia and arterial hypertension were more prevalent among patients with angina pectoris, current smoking status and elevated inflammatory markers, including total leukocyte and monocyte counts, were more likely associated with acute coronary events. Propensity score matching analysis, performed to eliminate the influence of these risk factors and highlight genetic modifiers, revealed that a single nucleotide variant, rs17735770 at the 3'untranslated region of the CCL7 gene transcript, was associated with decreased cardiovascular risk in a group represented mostly by men, with an average age of 57, and without significant differences in traditional risk factors. Furthermore, the presence of this variant altered the local mRNA structure encompassing a binding site for miR-23ab, resulting in increased translation of a reporter gene in a miR23 independent fashion. The rs17735770 genetic variant led to increased expression of CCL7, a potential antagonist of CCR2 at inflammatory sites, where it could play a meaningful role during the evolution of atherosclerosis.
URI: http://hdl.handle.net/10553/118888
DOI: 10.3389/fcvm.2022.908070
Fuente: Frontiers in Cardiovascular Medicine[EISSN 2297-055X],v. 9, (Mayo 2022)
Colección:Artículos
Adobe PDF (382,94 kB)
Vista completa

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.