Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/117852
Title: Assessment of SARS-CoV-2 Infection According to Previous Metabolic Status and Its Association with Mortality and Post-Acute COVID-19
Authors: De Arriba Fernández, Alejandro 
Alonso Bilbao, José Luis
Espiñeira Francés, Alberto
Cabeza Mora, Antonio
Gutiérrez Pérez, Ángela Trinidad 
Díaz Barreiros, Miguel Ángel
Serra Majem, Luis 
UNESCO Clasification: 32 Ciencias médicas
3206 Ciencias de la nutrición
320505 Enfermedades infecciosas
Keywords: Blood Lipids
Coronavirus Disease 2019
Fasting Glucose Levels
High-Density Lipoprotein Cholesterol
Mortality, et al
Issue Date: 2022
Journal: Nutrients 
Abstract: BACKGROUND: SARS-CoV-2 infection was analyzed according to previous metabolic status and its association with mortality and post-acute COVID-19. METHODS: A population-based observational retrospective study was conducted on a cohort of 110,726 patients aged 12 years or more who were diagnosed with COVID-19 infection between June 1st, 2021, and 28 February 2022 on the island of Gran Canaria, Spain. RESULTS: In the 347 patients who died, the combination of advanced age, male sex, cancer, immunosuppressive therapy, coronary heart disease, elevated total cholesterol and reduced high-density lipoprotein cholesterol (HDL-C) was strongly predictive of mortality (p < 0.05). In the 555 patients who developed post-acute COVID-19, the persistence of symptoms was most frequent in women, older subjects and patients with obstructive sleep apnea syndrome, asthma, elevated fasting glucose levels or elevated total cholesterol (p < 0.05). A complete vaccination schedule was associated with lower mortality (incidence rate ratio (IRR) 0.5, 95%CI 0.39-0.64; p < 0.05) and post-acute COVID-19 (IRR 0.37, 95%CI 0.31-0.44; p < 0.05). CONCLUSIONS: Elevated HDL-C and elevated total cholesterol were significantly associated with COVID-19 mortality. Elevated fasting glucose levels and elevated total cholesterol were risk factors for the development of post-acute COVID-19.
URI: http://hdl.handle.net/10553/117852
ISSN: 2072-6643
DOI: 10.3390/nu14142925
Source: Nutrients [EISSN 2072-6643],v. 14 (14), 2925, (Julio 2022)
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