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http://hdl.handle.net/10553/117852
Title: | Assessment of SARS-CoV-2 Infection According to Previous Metabolic Status and Its Association with Mortality and Post-Acute COVID-19 | Authors: | De Arriba Fernández, Alejandro Alonso Bilbao, José Luis Espiñeira Francés, Alberto Cabeza Mora, Antonio Gutiérrez Pérez, Ángela Trinidad Díaz Barreiros, Miguel Ángel Serra Majem, Luis |
UNESCO Clasification: | 32 Ciencias médicas 3206 Ciencias de la nutrición 320505 Enfermedades infecciosas |
Keywords: | Blood Lipids Coronavirus Disease 2019 Fasting Glucose Levels High-Density Lipoprotein Cholesterol Mortality, et al |
Issue Date: | 2022 | Journal: | Nutrients | Abstract: | BACKGROUND: SARS-CoV-2 infection was analyzed according to previous metabolic status and its association with mortality and post-acute COVID-19. METHODS: A population-based observational retrospective study was conducted on a cohort of 110,726 patients aged 12 years or more who were diagnosed with COVID-19 infection between June 1st, 2021, and 28 February 2022 on the island of Gran Canaria, Spain. RESULTS: In the 347 patients who died, the combination of advanced age, male sex, cancer, immunosuppressive therapy, coronary heart disease, elevated total cholesterol and reduced high-density lipoprotein cholesterol (HDL-C) was strongly predictive of mortality (p < 0.05). In the 555 patients who developed post-acute COVID-19, the persistence of symptoms was most frequent in women, older subjects and patients with obstructive sleep apnea syndrome, asthma, elevated fasting glucose levels or elevated total cholesterol (p < 0.05). A complete vaccination schedule was associated with lower mortality (incidence rate ratio (IRR) 0.5, 95%CI 0.39-0.64; p < 0.05) and post-acute COVID-19 (IRR 0.37, 95%CI 0.31-0.44; p < 0.05). CONCLUSIONS: Elevated HDL-C and elevated total cholesterol were significantly associated with COVID-19 mortality. Elevated fasting glucose levels and elevated total cholesterol were risk factors for the development of post-acute COVID-19. | URI: | http://hdl.handle.net/10553/117852 | ISSN: | 2072-6643 | DOI: | 10.3390/nu14142925 | Source: | Nutrients [EISSN 2072-6643],v. 14 (14), 2925, (Julio 2022) |
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