Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/114269
Título: Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
Autores/as: Carramiñana, Albert
Ferrando, Carlos
Unzueta, M. Carmen
Navarro, Ricard
Suárez-Sipmann, Fernando
Tusman, Gerardo
Garutti, Ignacio
Soro, Marina
Pozo, Natividad
Librero, Julián
Gallego, Lucía
Ramasco, Fernando
Rabanal, José M.
Rodriguez, Aurelio
Sastre, José
Martínez Milán, Jesús María
Coves, Silvia
López García, Patricia 
Aguirre-Puig, Pilar
Yepes, José
Lluch, Aitana
López-Herrera, Daniel
Leal, Sonsoles
Vives, Marc
Bellas, Soledad
Socorro, Tania
Trespalacios, Ramón
Salazar, Claudia J.
Mugarra, Ana
Cinnella, Gilda
Spadaro, Savino
Futier, Emmanuel
Ferrer, Leopoldo
Cabrera, María
Ribeiro, Helder
Celestino, Catarina
Kucur, Evrim
Cervantes, Oriol
Morocho, Diego
Delphy, Dalia
Ramos, Carolina
Villar, Jesús
Belda, Javier
Clasificación UNESCO: 32 Ciencias médicas
3205 Medicina interna
Palabras clave: Mechanical ventilation
One-lung ventilation
Positive end-expiratory pressure
Postoperative pulmonary complications
Recruitment maneuvers
Fecha de publicación: 2019
Publicación seriada: Journal of Cardiothoracic and Vascular Anesthesia 
Resumen: Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients.
URI: http://hdl.handle.net/10553/114269
ISSN: 1053-0770
DOI: 10.1053/j.jvca.2019.01.056
Fuente: Journal of Cardiothoracic and Vascular Anesthesia [ISSN 1053-0770], v. 33 (9), p. 2492-2502 (Septiembre 2019)
Colección:Artículos
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