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Title: Protective ostomies in ovarian cancer surgery: a systematic review and meta-analysis
Authors: Navarro Santana, Beatriz Fátima 
García Torralba, Esmeralda
Verdu Soriano, Jose
Laseca, Maria
Martín Martínez, Alicia 
UNESCO Clasification: 32 Ciencias médicas
320108 Ginecología
320101 Oncología
Keywords: Anastomotic Leak
Ovarian Neoplasms
Issue Date: 2022
Journal: Journal of Gynecologic Oncology 
Abstract: Objective: To assess the benefit of protective ostomies on anastomotic leak rate, urgent reoperations, and mortality due to anastomotic leak complications in ovarian cancer surgery. Methods: A systematic literature search was performed in MEDLINE, Web of Science,, and the Cochrane Central Register of Controlled Trials for all studies on anastomotic leak and ostomy formation related to ovarian cancer surgery. Non-controlled studies, case series, abstracts, case reports, study protocols, and letters to the editor were excluded. Meta-analysis was performed on the primary endpoint of anastomotic leak rate. Subgroup analysis was carried out based on type of bowel resection and bevacizumab use. Secondary endpoints were urgent re-operations and mortality associated with anastomotic leak, length of hospital stay, postoperative complications, 30-day readmission rate, adjuvant chemotherapy, survival, and reversal surgery in ostomy and non-ostomy patients. Results: A total of 17 studies (2,719 patients) were included: 16 retrospective cohort studies, and 1 case-control study. Meta-analysis of 17 studies did not show a decrease in anastomotic leak rate in ostomy patients (odds ratio [OR]=1.01; 95% confidence interval [CI]=0.60–1.70; p=0.980). Meta-analysis of ten studies (1,452 women) did not find a decrease in urgent reoperations in the ostomy group (OR=0.72; 95% CI=0.35–1.46; p=0.360). Other outcomes were not considered for meta-analysis due to the lack of data in included studies. Conclusion: Protective ostomies did not decrease anastomotic leak rates, and urgent re-operations in ovarian cancer surgery. This evidence supports the use of ostomies in very select cases.
ISSN: 2005-0380
DOI: 10.3802/jgo.2022.33.e21
Source: Journal of Gynecologic Oncology [ISSN 2005-0380], v. 33 (2), e21, (Marzo 2022)
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