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Title: Fabric Phase Sorptive Extraction for the Determination of Anthracyclines in Sewage
Authors: Santana Viera, Sergio 
Canino Byreing, Alejandro
Torres Padrón, María Esther 
Sosa Ferrera, María Zoraida 
Santana Rodríguez, José Juan 
Kabir, Abuzar
Furton, Kenneth G.
UNESCO Clasification: 330201 Tecnología de los antibióticos
330810 Tecnología de aguas residuales
332817 Extracción liquido-liquido
Keywords: Antineoplastic compounds
Emerging pollutants
Fabric phase sorptive extraction
Microextraction techniques
Ultra-high performance liquid cromatography-fluorescense detector
Issue Date: 2022
Journal: Separations 
Abstract: Anthracyclines are a group of antineoplastic compounds used to treat acute leukemia and other cancers, and they are excreted after consumption by patients. These chemicals are often found in sewage at very low concentration levels. For this reason, the development of sensitive analytical methodologies capable of determining them at low concentrations is of prime importance. A simple, fast and sensitive analytical method using fabric phase sorptive extraction (FPSE) followed by ultra-high performance liquid chromatography with fluorescence detection (UHPLC-FD) has been developed and validated for the extraction of anthracyclines from sewage samples. FPSE is a green, cheap, simple, selective and rapid sample preparation technique. The different parameters that affect the performance of the FPSE process, including extraction time, eluting solvent, elution time and pH, were optimized. The developed method showed satisfactory reproducibility, with intraday and interday RSD values lower than 15% for all the compounds and limits of detection between 0.1–0.15 µg·L−1. The unique combination of sample preparation by this micro-extraction technique with fluorescence detector have resulted in the satisfactory extraction of highly polar anthracyclines, without any noticeable matrix effect, a very common shortcoming of exhaustive sample preparation technique such as solid phase extraction (SPE) and mass spectrometry.
ISSN: 2297-8739
DOI: 10.3390/separations9030069
Source: Separations [EISSN 2297-8739], v. 9 (3), 69, (Marzo 2022)
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