Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/113851
Title: Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial
Authors: Tresserra-Rimbau, Anna
Castro-Barquero, Sara
Becerra-Tomás, Nerea
Babio, Nancy
Martínez-González, Miguel Ángel
Corella, Dolores
Fitó, Montserrat
Romaguera, Dora
Vioque, Jesús
Alonso-Gomez, Angel M.
Wärnberg, Julia
Martínez, José Alfredo
Serra Majem, Luis 
Estruch, Ramon
Tinahones, Francisco J.
Lapetra, José
Pintó, Xavier
Tur, Josep A.
López-Miranda, José
Cano-Ibáñez, Naomi
Delgado-Rodríguez, Miguel
Matía-Martín, Pilar
Daimiel, Lidia
Sánchez, Vicente Martín
Vidal, Josep
Vázquez, Clotilde
Ros, Emili
Basterra, Francisco Javier
de la Puente, María Fernández
Asensio, Eva M.
Castañer, Olga
Bullón-Vela, Vanessa
Tojal-Sierra, Lucas
Gómez-Gracia, Enrique
Cases-Pérez, Eugenio
Konieczna, Jadwiga
García-Ríos, Antonio
Casañas-Quintana, Tamara
Bernal-Lopez, María Rosa
Santos-Lozano, José Manuel
Esteve-Luque, Virginia
Bouzas, Cristina
Vázquez-Ruiz, Zenaida
Palau-Galindo, Antoni
Barragan, Rocio
Grau, Mercè López
Razquín, Cristina
Goicolea-Güemez, Leire
Toledo, Estefanía
Vergaz, Manel Vila
Lamuela-Raventós, Rosa M.
Salas-Salvadó, Jordi
UNESCO Clasification: 32 Ciencias médicas
3206 Ciencias de la nutrición
Keywords: Antioxidants
Flavonoids
Glucose
Glycosylated Hemoglobin
Hba1C, et al
Issue Date: 2022
Project: Efecto de la dieta mediterránea hopocalórica y promoción de la actividad física en prevención primaria cardiovascular.Estudio piloto sobre marcadores intermedios. 
Efecto de Una Pérdida de Peso Con Dieta Mediterránea Hipocalórica y Promoción de la Actividad Física en la Prevención Primaria Cardiovascular 
Efecto de una intervención intensiva de pérdida de peso con dieta Mediterránea hipocalórica, actividad física y tratamiento conductual sobre la prevención primaria cardiovascular: ensayo PREDIMED-Plus 
Journal: Antioxidants 
Abstract: Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a vali-dated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D.
URI: http://hdl.handle.net/10553/113851
ISSN: 2076-3921
DOI: 10.3390/antiox11020316
Source: Antioxidants[EISSN 2076-3921],v. 11 (2), (Febrero 2022)
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