On the use of patterns obtained from LSTM and feature-based methods for time series analysis: application in automatic classification of the CAP A phase subtypes

Abstract

The cyclic alternating pattern is a marker of sleep instability identified in the electroencephalogram signals whose sequence of transient variations compose the A phases. These phases are divided into three subtypes (A1, A2, and A3) according to the presented patterns. The traditional approach of manually scoring the cyclic alternating pattern events for the full night is unpractical, with a high probability of miss classification, due to the large quantity of information that is produced during a full night recording. To address this concern, automatic methodologies were proposed using a long short-term memory to perform the classification of one electroencephalogram monopolar derivation signal. The proposed model is composed of three classifiers, one for each subtype, performing binary classification in a one versus all procedure. Two methodologies were tested: feed the pre-processed electroencephalogram signal to the classifiers; create features from the pre-processed electroencephalogram signal which were fed to the classifiers (feature-based methods). It was verified that the A1 subtype classification performance was similar for both methods and the A2 subtype classification was higher for the feature-based methods. However, the A3 subtype classification was found to be the most challenging to be performed, and for this classification, the feature-based methods were superior. A characterization analysis was also performed using a recurrence quantification analysis to further examine the subtypes characteristics. The average accuracy and area under the receiver operating characteristic curve for the A1, A2, and A3 subtypes of the feature-based methods were respectively: 82% and 0.92; 80% and 0.88; 85% and 0.86.