Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/105838
Title: Oral administration of lipopolysaccharides from Escherichia coli (serotype O111:B4) does not induce an effective systemic immune response in milk-fed Holstein calves
Authors: Samarasinghe, M.B.
Sehested, J.
Larsen, T.
Hernández Castellano, Lorenzo Enrique 
UNESCO Clasification: 3104 Producción Animal
310907 Patología
310903 Inmunología
Keywords: Escherichia coli
Calves
Immune system
Lipopolysaccharides
Issue Date: 2020
Journal: Journal of Dairy Science 
Abstract: It is well established that intravenous administration of lipopolysaccharides (LPS)-cell wall components from gram-negative bacteria-induce acute inflammatory responses in dairy calves, but the effect of oral administration of LPS to dairy calves is currently unknown. To evaluate the effects of oral administration of LPS derived from Escherichia coli (serotype O111:B4) on innate immune responses in milk-fed Holstein calves, 20 visually healthy calves (34 ± 1 d) received 4 L of milk with LPS (12 μg/kg body weight; n = 10; LPS) or without LPS (n = 10; control) at the morning feeding. Samples were collected at 0.5 h before the morning feeding and at 3, 6, 24, 48, 72, and 168 h after the morning feeding to measure rectal temperature and heart rate, as well as plasma-negative and plasma-positive acute phase proteins (i.e., haptoglobin, serum amyloid A, albumin, total protein, and fibrinogen) and immunoglobulin concentrations (IgG, IgM, and IgA). None of these measurements was affected by the oral administration of LPS. Oral administration of LPS at 12 μg/kg of body weight did not induce an acute inflammatory response in visually healthy milk-fed Holstein calves when administered in milk.
URI: http://hdl.handle.net/10553/105838
ISSN: 0022-0302
DOI: 10.3168/jds.2019-17404
Source: Journal of Dairy Science [ISSN 0022-0302], v. 103(6), p. 5525-5531
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