Angiogenesis And Helminths

Abstract

The studies about the role of angiogenic and antiangiogenic factors in the biology of tumor growth and development of metastases are most abundant in the literature. However, both the generation and inhibition of new vessel formation plays an important role in other pathophysiological processes like ischemia, infection and inflammation.Firstly, we briefly point out the basic concepts of angiogenesis and vasculogenesis, as well as their role in neoplastic and non-neoplastic diseases.In addition, we study the characteristics of the two major angiogenic factors: vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2). Specifically, the structural features of the above factors and the biological mechanism of action will be indicated. Also, antiangiogenic factors as endostatin, a potent inhibitor of endothelial cell proliferation, migration, angiogenesis and tumor growth will be studied.Finally, we discuss the role of angiogenic and antiangiogenic factors in the pathogenesis of helminthic diseases. Until now, only very little information has been found and virtually confined to infection with Schistosomaspp, filarial species, Taeniasolium and Trichinella spp.For this reason, author interested to study more about parasites and angiogenesis, probably relationship between them, could be open a good way for prevent and treatment of parasite diseases and maybe cancer.