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http://hdl.handle.net/10553/70027
Título: | Pulmonary nodules: An unusual onset of HIV infection belatedly diagnosed | Autores/as: | Bastón Paz, Natalia Hernández Betancor, Araceli Esparza Morera, Rafael Báez Acosta, Beatriz Santana Rodríguez, Évora Martín Sánchez, Antonio Manuel |
Clasificación UNESCO: | 320505 Enfermedades infecciosas 320508 Enfermedades pulmonares |
Palabras clave: | Cryptococcus Neoformans Histopathology Hiv Pulmonary Cryptococcosis |
Fecha de publicación: | 2019 | Publicación seriada: | Revista Iberoamericana de Micologia | Resumen: | Background: Cryptococcosis is a generally systemic and potentially lethal fungal infection. Although HIV infection is a predisposing condition, especially if the CD4+ lymphocyte count is less than 100 cells/mm3, other forms of immunosuppression may be associated with this opportunistic fungal condition, such as prolonged steroid therapy or solid organ transplantation. Pulmonary presentation must be included in the differential diagnosis of pneumonia or pulmonary neoplasia in the immunosuppressed patient. Case report: We report a case of pulmonary cryptococcosis in a non-diagnosed HIV patient. In a 44 year-old male suffering from dyspnea and chest pain the image of a pulmonary nodule was observed in a radiological finding. In the histopathological study, intracellular structures suggestive of fungal conidia, and morphologically compatible with Cryptococcus, were observed. HIV serology and cryptococcal antigen detection in serum were requested, given the possibility of cryptococcosis. Cryptococcus neoformans var. grubii was isolated from the culture of the pulmonary biopsy. The patient was finally diagnosed with pulmonary cryptococcosis and HIV-1 infection. With a proper antifungal treatment the patient evolved satisfactorily. Conclusions: The best strategy to avoid opportunistic infections such as cryptococcosis in HIV-infected patients consists of an early diagnosis and a highly active antiretroviral treatment. In our case, the diagnosis of a pulmonary infection by C. neoformans var. grubii allowed a late diagnosis of HIV-1 infection. | URI: | http://hdl.handle.net/10553/70027 | ISSN: | 1130-1406 | DOI: | 10.1016/j.riam.2019.04.005 | Fuente: | Revista Iberoamericana de Micologia [ISSN 1130-1406], v. 36 (3), p. 151-154 |
Colección: | Artículos |
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actualizado el 05-ago-2023
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