Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/54581
Título: Evaluation of the role of angiogenic factors in the pathogenesis of schistosomiasis
Autores/as: Shariati, F.
Pérez-Arellano, J. L. 
Carranza Rodríguez, Cristina 
López-Abán, J.
Vicente, B.
Arefi, M.
Muro, A.
Clasificación UNESCO: 32 Ciencias médicas
320712 Parasitología
Palabras clave: Schistosoma mansoni
Schistosomiasis
Angiogenesis
VEGF
Endostatin, et al.
Fecha de publicación: 2011
Publicación seriada: Experimental parasitology 
Resumen: Schistosomiasis is one disease produced by helminths, which affect many people in tropical areas. Granuloma formation is the main mechanism involved in the pathogenesis of this disease. Experimental studies have demonstrated angiogenesis (blood vessels formation from pre-existing vessels) in the initial phase of granuloma formation. In the present work, VEGF (vascular endothelial growth factor) levels were analyzed in sera from people diagnosed with different helminthic infections. Patients with schistosomiasis and filariasis had significantly high VEGF levels in compared with healthy people and patients diagnosed with hookworms. In addition, the effects of angiogenesis inhibition using anti-angiogenic factors (endostatin) were evaluated in a schistosomiasis murine model. A lesion decrease was observed in mice infected with Schistosoma mansoni and treated with endostatin. Finally, mechanisms of angiogenesis induction were studied and observed that cercariae antigens stimulated the angiogenic factors by host alveolar macrophages.
URI: http://hdl.handle.net/10553/54581
ISSN: 0014-4894
DOI: 10.1016/j.exppara.2011.01.016
Fuente: Experimental Parasitology [ISSN 0014-4894], v. 128(1), p. 44-49 (Mayo 2011)
Colección:Artículos
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