Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/52333
Title: Dual role of LOH at MMR loci in hereditary non-polyposis colorectal cancer?
Authors: Sanchez De Abajo, A. 
De La Hoya, M.
Van Puijenbroek, M.
Godino, J.
Díaz-Rubio, E.
Morreau, H.
Caldes, T.
UNESCO Clasification: 32 Ciencias médicas
320713 Oncología
Keywords: LOH
HNPCC
MMR
Issue Date: 2006
Journal: Oncogene 
Abstract: hMLH1 and hMSH2 can be considered tumor suppressor genes, as both alleles must be inactivated in order to lose the mismatch repair (MMR) function. In this regard, it has been proposed that LOH at MMR loci is a common Knudson's second-hit mechanism in HNPCC patients. However, experimental evidence supporting this view is scarcely found in the literature. We have performed a comprehensive analysis of LOH in 45 HNPCC tumors carrying a germline alteration in MMR loci. Overall, we have detected LOH at MMR loci in 56% of the cases. However, up to 40% of the LOH events targeted the mutant allele, arguing against a second-hit role in these tumors. Interestingly, the age at diagnosis was significantly older in these patients. To explain this and previous data, we propose a dual role for LOH at MMR loci in HNPCC.
URI: http://hdl.handle.net/10553/52333
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1209233
Source: Oncogene[ISSN 0950-9232],v. 25, p. 2124-2130 (Marzo 2006)
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