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http://hdl.handle.net/10553/50832
| Título: | Progestin augmentation of gonadotropin-stimulated progesterone production by cultured rat granulosa cells | Autores/as: | Fanjul, L. F. Ruiz De Galarreta Hernandez,C. Manuel Hsueh, Aaron J.W. |
Clasificación UNESCO: | 32 Ciencias médicas 3201 Ciencias clínicas 320502 Endocrinología |
Palabras clave: | Progestin Gonadotropin Progesterone Rat |
Fecha de publicación: | 1983 | Publicación seriada: | Endocrinology (Philadelphia) | Resumen: | Ovarian progesterone production is stimulated by FSH and LH. Concomitant treatment with a synthetic progestin, R5020, (10-6 M) increases the FSH-stimulated production of progesterone and 20α-hydroxypregn-4-en-3-one (20α-OH-P) in cultured rat granulosa cells. Likewise, R5020 augments the LH-stimulated progestin production in FSH-primed cells. Furthermore, the FSH stimulation of pregnenolone biosynthesis is enhanced by 10-6 M of progesterone or R5020. These in vitro findings suggest that progestins may exert an autoregulatory positive feedback action to enhance gonadotropin-stimulated production of progesterone and 20α-OH-P. | URI: | http://hdl.handle.net/10553/50832 | ISSN: | 0013-7227 | DOI: | 10.1210/endo-112-1-405 | Fuente: | Endocrinology[ISSN 0013-7227],v. 112(1), p. 405-407 (Enero 1983) |
| Colección: | Artículos |
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