Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/47728
Título: Brain ischemia and hypometabolism treated by ozone therapy
Autores/as: Clavo, Bernardino 
Suarez, Gerardo
Aguilar, Yolanda
Gutierrez, Dominga
Ponce, Pedro
Cubero, Alberto
Robaina, Francisco
Carreras, Jose L.
Clasificación UNESCO: 32 Ciencias médicas
321308 Neurocirugía
Palabras clave: Single photon emission computed tomography
SPECT
Ozone therapy
Positron emission tomography
PET, et al.
Fecha de publicación: 2011
Publicación seriada: Forschende Komplementarmedizin (2006) 
Resumen: Background: Radiation-induced brain injury (RBI) and low-perfusion brain syndromes are mediated by ischemia and hypometabolism and have limited treatment options. Ozone therapy as treatment in vascular diseases has been described, but the effects on brain tissue have not been well documented. Case Report: We describe a 75-year-old patient with vascular risk factors and meningioma who was treated with stereotactic radiosurgery. 14 months later the patient presented with progressive clinical impairment despite the use of acetylsalicylic acid and corticosteroids. Clinical and imaging evaluations before/after ozone therapy were done by magnetic resonance imaging (MRI), computed tomography (CT), single photon emission computed tomography (SPECT), and positron emission tomography (PET); performance status assessment was done using Barthel Index and World Health Organization/Eastern Cooperative Oncology Group Scale (WHO/ECOG Scale). Ozone therapy was performed by autohemotransfusion. Results: Basal images showed brain areas with ischemia and hypometabolism compatible with ischemic processes and/or RBI. There were no changes in MRI or CT scan images following ozone therapy. However, improvements in brain perfusion and metabolism were demonstrable with SPECT and PET; they correlated with clinical development and performance status scales. Conclusion: This report supports our previous works about the effect of ozone therapy in cerebral blood flow, and it suggests the use of ozone therapy in ischemic and hypometabolic brain syndromes such as stroke or RBI.
URI: http://hdl.handle.net/10553/47728
ISSN: 1661-4119
DOI: 10.1159/000333795
Fuente: Forschende Komplementarmedizin [ISSN 1661-4119],v. 18(5), p. 283-287
Colección:Artículos
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