Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/46617
Título: Drug-resistant pneumococcal pneumonia: Clinical relevance and related factors
Autores/as: Aspa, Javier
Rajas, Olga
De Castro, Felipe Rodríguez 
Blanquer, José
Zalacain, Rafael
Fenoll, Asunción
De Celis, Rosa
Vargas, Antonio
Salvanés, Francisco Rodríguez
España, Pedro Pablo
Rello, Jordi
Torres, Antoni
Clasificación UNESCO: 32 Ciencias médicas
320505 Enfermedades infecciosas
320508 Enfermedades pulmonares
Palabras clave: Erythromycin
Lung diseases
Penicillin
Bacteremia
Community acquired pneumonia, et al.
Fecha de publicación: 2004
Publicación seriada: Clinical Infectious Diseases 
Resumen: A multicenter study of 638 cases of community-acquired pneumonia due to Streptococcus pneumoniae (SP-CAP) was performed to assess current levels of resistance. Of the pneumococcal strains, 35.7% had an minimum inhibitory concentration (MIC) of penicillin of ⩾0.12 µg/mL (3 isolates had an MIC of 4 µg/mL), 23.8% had an MIC of erythromycin of 128 µg/mL, and 22.2% were multidrug resistant. Logistic regression determined that chronic pulmonary disease (odds ratio [OR], 1.44], human immunodeficiency virus infection (OR, 1.98), clinically suspected aspiration (OR, 2.12), and previous hospital admission (OR, 1.69) were related to decreased susceptibility to penicillin, and previous admission (OR, 1.89) and an MIC of penicillin of MIC ⩾0.12 µg/mL (OR, 15.85) were related to erythromycin resistance (MIC, ⩾1 µg/mL). The overall mortality rate was 14.4%. Disseminated intravascular coagulation, empyema, and bacteremia were significantly more frequent among patients with penicillin-susceptible SP-CAP. Among isolates with MICs of penicillin of ⩾0.12 µg/mL, serotype 19 was predominant and was associated with a higher mortality rate. In summary, the rate of resistance to β-lactams and macrolides among S. pneumoniae that cause CAP remains high, but such resistance does not result in increased morbidity.
URI: http://hdl.handle.net/10553/46617
ISSN: 1058-4838
DOI: 10.1086/381886
Fuente: Clinical Infectious Diseases [ISSN 1058-4838],v. 38, p. 787-798
Colección:Artículos
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