Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/43344
Título: | Morphologic and immunohistochemical features of Merkel cells in the dog | Autores/as: | Ramírez, G. A. Rodríguez Guisado, Francisco Herráez Thomas, Pedro Manuel Suárez Bonnet, Alejandro Andrada Borzollino, Marisa Ana Espinosa De Los Monteros Y Zayas, Antonio |
Clasificación UNESCO: | 310907 Patología | Palabras clave: | Dogs Immunohistochemistry Merkel cell Neuroendocrine Skin |
Fecha de publicación: | 2014 | Editor/a: | 0034-5288 | Publicación seriada: | Research in Veterinary Science | Resumen: | Merkel cells (MCs) are specialized skin receptors characterized by their particular location and close association with nerve terminals. They also are cells with a presumptive neuroendocrine function and are considered as part of the diffuse neuroendocrine system. By using commercially available monoclonal and polyclonal antibodies in samples of dog skin, MCs were properly distinguished from other clear cell types in the epidermis. They expressed cytokeratins 7, 8, 20, EpCAM, NSE, CGA, SYN, S100 protein, and NF, presented diverse cytological features and arrangements depending on the location considered, and showed pronounced heterogeneity with markedly different expression and distribution patterns for antibodies used. Anti-CK20 presented as the most reliable and specific antibody for their identification. The present study increases our knowledge of MCs and establishes a basis for future studies of the role(s) of the MCs in diseased tissues of the dog skin, including the cutaneous neuroendocrine (Merkel cell) tumour. | URI: | http://hdl.handle.net/10553/43344 | ISSN: | 0034-5288 | DOI: | 10.1016/j.rvsc.2014.10.006 | Fuente: | Research in Veterinary Science [ISSN 0034-5288], v. 97(3), p. 475-480 |
Colección: | Artículos |
Citas SCOPUSTM
16
actualizado el 15-dic-2024
Citas de WEB OF SCIENCETM
Citations
13
actualizado el 15-dic-2024
Visitas
124
actualizado el 07-dic-2024
Google ScholarTM
Verifica
Altmetric
Comparte
Exporta metadatos
Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.