Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/37108
Título: Endomyocardial involvement in asymptomatic sub-Saharan immigrants with helminth-related eosinophilia
Autores/as: Carranza Rodríguez, Cristina 
San Román Sánchez, Daniel 
Marrero-Santiago, H.
Hernández-Cabrera, Michele 
Gil-Guillén, Carlos
Pisos Álamo, E. 
Jaén-Sánchez, Nieves
Pérez-Arellano, José L. 
Coordinadores/as, Directores/as o Editores/as: Klion, Amy D.
Clasificación UNESCO: 320505 Enfermedades infecciosas
Palabras clave: Eosinophilia
Fecha de publicación: 2017
Publicación seriada: PLoS Neglected Tropical Diseases 
Resumen: Background Among immigrants of sub-Saharan origin, parasitic infection is the leading cause of eosinophilia, which is generally interpreted as a defense mechanism. A side effect of the inflammatory mediators released by eosinophils is damage to host organs, especially the heart. The main objectives of this study were to i) assess cardiac involvement in asymptomatic sub-Saharan immigrants with eosinophilia, ii) relate the presence of lesions with the degree of eosinophilia, and iii) study the relationship between cardiac involvement and the type of causative parasite. Methodology/Principle findings In total, the study included 50 black immigrants (37 patients and 13 controls) from sub-Saharan Africa. In all subjects, heart structure and function were evaluated in a blinded manner using Sonos 5500 echocardiographic equipment. The findings were classified and described according to established criteria. The diagnostic criteria for helminthosis were those reported in the literature. Serum eosinophil-derived neurotoxin levels were measured using enzyme-linked immunosorbent assay. A significant association was found between the presence of eosinophilia and structural alterations (mitral valve thickening). However, the lack of an association between the degree of eosinophilia and heart valve disease and the absence of valve involvement in some patients with eosinophilia suggest the role of other factors in the appearance of endocardial lesions. There was also no association between the type of helminth and valve involvement. Conclusions We, therefore, suggest that transthoracic echocardiography be performed in every subSaharan individual with eosinophilia in order to rule out early heart valve lesions.
URI: http://hdl.handle.net/10553/37108
ISSN: 1935-2727
DOI: 10.1371/journal.pntd.0005403
Fuente: PLoS Neglected Tropical Diseases [ISSN 1935-2727], v. 11 (2), e0005403
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