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http://hdl.handle.net/10553/35489
Título: | The Mediterranean Diet decreases LDL atherogenicity in high cardiovascular risk individuals: a randomized controlled trial | Autores/as: | Hernáez, Alvaro Castañer, O. Goday, Alberto Ros, Emilio Pintó, Xavier Estruch, Ramón Salas-Salvadó, Jordi Corella, Dolores Arós, Fernando Serra-Majem, Lluis Martínez-González, Miguel Ángel Fiol, Miquel Lapetra, José de la Torre, R. López-Sabater, M. Carmen Fitó, Montse |
Clasificación UNESCO: | 3206 Ciencias de la nutrición | Palabras clave: | LDL cytotoxicity LDL oxidation LDL size Low density lipoproteins Mediterranean diet |
Fecha de publicación: | 2017 | Publicación seriada: | Molecular Nutrition and Food Research | Resumen: | Scope: Traditional Mediterranean diet (TMD) protects against cardiovascular disease through several mechanisms such as decreasing LDL cholesterol levels. However, evidence regarding TMD effects on LDL atherogenic traits (resistance against oxidation, size, composition, cytotoxicity) is scarce. Methods and results: We assessed the effects of a 1-year intervention with a TMD on LDL atherogenic traits in a random sub-sample of individuals from the PREDIMED study (N= 210). We compared two TMDs: one enriched with virgin olive oil (TMD-VOO, N = 71) and another with nuts (TMD-Nuts, N = 68), versus a low-fat control diet (N = 71). After the TMD-VOO intervention, LDL resistance against oxidation increased (+6.46%, p = 0.007), the degree of LDL oxidative modifications decreased (-36.3%, p<0.05), estimated LDL particle size augmented (+3.06%, p = 0.021), and LDL particles became cholesterol-rich (+2.41% p = 0.013) relative to the low-fat control diet. LDL lipoproteins became less cytotoxic for macrophages only relative to baseline (-13.4%, p = 0.019). No significant effects of the TMD-Nuts intervention on LDL traits were observed versus the control diet. Conclusion: Adherence to a TMD, particularly when enriched with virgin olive oil, decreased LDL atherogenicity in high cardiovascular risk individuals. The development of less atherogenic LDLs could contribute to explaining some of the cardioprotective benefits of this dietary pattern. | URI: | http://hdl.handle.net/10553/35489 | ISSN: | 1613-4125 | DOI: | 10.1002/mnfr.201601015 | Fuente: | Molecular Nutrition and Food Research [ISSN 1613-4125], v. 61 (9), article number 1601015 |
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