Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/9025
Campo DC Valoridioma
dc.contributor.authorHenríquez Hernández, Luis Albertoen_US
dc.contributor.authorLara Jiménez, Pedro Carlosen_US
dc.contributor.authorPinar, Beatrizen_US
dc.contributor.authorBordón, Elisaen_US
dc.contributor.authorRodríguez-Gallego, Carlosen_US
dc.contributor.authorBilbao, Cristinaen_US
dc.contributor.authorFernandez-Perez, Leandroen_US
dc.contributor.authorFlores Morales, Amílcaren_US
dc.contributor.otherBILBAO SIEYRO, CRISTINA-
dc.contributor.otherFernandez-Perez, Leandro-
dc.contributor.otherBordon Rodriguez, Elisa-
dc.date.accessioned2012-11-16T11:59:00Z-
dc.date.accessioned2018-04-25T13:59:38Z-
dc.date.available2012-11-16T11:59:00Z-
dc.date.available2018-04-25T13:59:38Z-
dc.date.issued2009en_US
dc.identifierhttp://dx.doi.org/10.1186/1748-717X-4-17-
dc.identifier.issn1748-717Xen_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/9025-
dc.description.abstractBreast cancer patients show a wide variation in normal tissue reactions after radiotherapy. The individual sensitivity to x-rays limits the efficiency of the therapy. Prediction of individual sensitivity to radiotherapy could help to select the radiation protocol and to improve treatment results. The aim of this study was to assess the relationship between gene expression profiles of ex vivo un-irradiated and irradiated lymphocytes and the development of toxicity due to high-dose hyperfractionated radiotherapy in patients with locally advanced breast cancer. Raw data from microarray experiments were uploaded to the Gene Expression Omnibus Database http://www.ncbi.nlm.nih.gov/geo/ (GEO accession GSE15341). We obtained a small group of 81 genes significantly regulated by radiotherapy, lumped in 50 relevant pathways. Using ANOVA and t-test statistical tools we found 20 and 26 constitutive genes (0 Gy) that segregate patients with and without acute and late toxicity, respectively. Non-supervised hierarchical clustering was used for the visualization of results. Six and 9 pathways were significantly regulated respectively. Concerning to irradiated lymphocytes (2 Gy), we founded 29 genes that separate patients with acute toxicity and without it. Those genes were gathered in 4 significant pathways. We could not identify a set of genes that segregates patients with and without late toxicity. In conclusion, we have found an association between the constitutive gene expression profile of peripheral blood lymphocytes and the development of acute and late toxicity in consecutive, unselected patients. These observations suggest the possibility of predicting normal tissue response to irradiation in high-dose non-conventional radiation therapy regimens. Prospective studies with higher number of patients are needed to validate these preliminary results.en_US
dc.languageengen_US
dc.relation.ispartofRadiation Oncologyen_US
dc.sourceRadiation Oncology[ISSN 1748-717X],v. 4en_US
dc.subject320101 Oncologíaen_US
dc.subject.otherOnto-Toolsen_US
dc.subject.otherIonizing-Radiationen_US
dc.subject.otherDna-Damageen_US
dc.subject.otherStage-Iiien_US
dc.subject.otherDesignen_US
dc.subject.otherHeaden_US
dc.subject.otherNecken_US
dc.titleConstitutive gene expression profile segregates toxicity in locally advanced breast cancer patients treated with high-dose hyperfractionated radical radiotherapyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1748-717X-4-17en_US
dc.identifier.scopus2-s2.0-67749124619-
dc.identifier.isi000267319300001-
dcterms.isPartOfRadiation Oncology-
dcterms.sourceRadiation Oncology[ISSN 1748-717X],v. 4-
dc.date.updated2012-11-12T18:50:03Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066en-
dc.rights.holderLuis Henríquez Hernández et al.; licensee BioMed Central Ltd.-
dc.compliance.driver1-
dc.contributor.authorscopusid15829708200-
dc.contributor.authorscopusid7004374085-
dc.contributor.authorscopusid6507421079-
dc.contributor.authorscopusid24402677200-
dc.contributor.authorscopusid6602114379-
dc.contributor.authorscopusid12759635600-
dc.contributor.authorscopusid6506777525-
dc.contributor.authorscopusid57203543352-
dc.identifier.crisid12688;325;21987;-;-;17907;2167;--
dc.identifier.eissn1748-717X-
dc.relation.volume4en_US
dc.investigacionCiencias de la Saluden_US
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess-
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess-
dc.type2Artículoen_US
dc.identifier.wosWOS:000267319300001-
dc.contributor.daisngid528281-
dc.contributor.daisngid465624-
dc.contributor.daisngid591076-
dc.contributor.daisngid1285881-
dc.contributor.daisngid2045042-
dc.contributor.daisngid382642-
dc.contributor.daisngid5056255-
dc.contributor.daisngid2205075-
dc.contributor.daisngid795544-
dc.contributor.daisngid1668123-
dc.identifier.investigatorRIDR-6779-2018-
dc.identifier.investigatorRIDH-1493-2015-
dc.identifier.investigatorRIDH-9033-2015-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Hernandez, LAH-
dc.contributor.wosstandardWOS:Lara, PC-
dc.contributor.wosstandardWOS:Pinar, B-
dc.contributor.wosstandardWOS:Bordon, E-
dc.contributor.wosstandardWOS:Gallego, CR-
dc.contributor.wosstandardWOS:Bilbao, C-
dc.contributor.wosstandardWOS:Perez, LF-
dc.contributor.wosstandardWOS:Morales, AF-
dc.date.coverdateJunio 2009en_US
dc.identifier.supplementhttp://dx.doi.org/10.1186/1748-717X-4-17-
dc.identifier.supplement12688;325;21987;-;-;17907;2167;--
dc.identifier.ulpgces
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.orcid0000-0002-4796-1445-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNameBilbao Sieyro, Cristina-
crisitem.author.fullNameFernández Pérez, Leandro Francisco-
Colección:Artículos
miniatura
Adobe PDF (620,58 kB)
Microsoft Word (30,5 kB)
Microsoft Excel (43 kB)
Microsoft Excel (21 kB)
Microsoft Excel (135,5 kB)
Microsoft Word (50 kB)
Microsoft Excel (48,5 kB)
Microsoft Excel (75,5 kB)
Microsoft Excel (50 kB)
XML (80,68 kB)
Vista resumida

Citas SCOPUSTM   

28
actualizado el 08-dic-2024

Citas de WEB OF SCIENCETM
Citations

20
actualizado el 08-dic-2024

Visitas

96
actualizado el 04-may-2024

Descargas

135
actualizado el 04-may-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.