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Title: MVP and Vaults: a role in the radiation response
Authors: Lara Jiménez, Pedro Carlos 
Pruschy, Martin
Zimmermann, Martina
Henríquez Hernández, Luis Alberto 
UNESCO Clasification: 320101 Oncología
Keywords: Major vault protein
Radiation response
Issue Date: 2011
Journal: Radiation Oncology 
Abstract: Vaults are evolutionary highly conserved ribonucleoproteins particles with a hollow barrel-like structure. The main component of vaults represents the 110 kDa major vault protein (MVP), whereas two minor vaults proteins comprise the 193 kDa vault poly(ADP-ribose) polymerase (vPARP) and the 240 kDa telomerase-associated protein-1 (TEP-1). Additionally, at least one small and untranslated RNA is found as a constitutive component. MVP seems to play an important role in the development of multidrug resistance. This particle has also been implicated in the regulation of several cellular processes including transport mechanisms, signal transmission and immune responses. Vaults are considered a prognostic marker for different cancer types. The level of MVP expression predicts the clinical outcome after chemotherapy in different tumour types. Recently, new roles have been assigned to MVP and vaults including the association with the insulin-like growth factor-1, hypoxia-inducible factor-1alpha, and the two major DNA double-strand break repair machineries: non-homologous endjoining and homologous recombination. Furthermore, MVP has been proposed as a useful prognostic factor associated with radiotherapy resistance. Here, we review these novel actions of vaults and discuss a putative role of MVP and vaults in the response to radiotherapy.
ISSN: 1748-717X
Other Identifiers:
DOI: 10.1186/1748-717X-6-148
Source: Radiation Oncology [ISSN 1748-717X], 2011, n. 6, p. 148
Appears in Collections:Reseña
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