Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/8999
Campo DC Valoridioma
dc.contributor.authorHenríquez Hernández, Luis Albertoen_US
dc.contributor.authorMoreno, Mercedesen_US
dc.contributor.authorRey, Agustínen_US
dc.contributor.authorLloret Saez-Bravo, Martaen_US
dc.contributor.authorLara Jiménez, Pedro Carlosen_US
dc.date.accessioned2012-11-12T08:55:41Z-
dc.date.accessioned2018-04-25T13:58:55Z-
dc.date.available2012-11-12T08:55:41Z-
dc.date.available2018-04-25T13:58:55Z-
dc.date.issued2012en_US
dc.identifierhttp://dx.doi.org/10.1186/1748-717X-7-147-
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/8999-
dc.description.abstractObjective: To explore the role of Major Vault Protein (MVP) in oral cavity squamous cell carcinoma patients. Subjects and Methods: 131 consecutive patients suffering from oral cavity squamous cell carcinoma were included in the study. In the whole series, the mean follow-up for survivors was 123.11 ± 40.36 months. Patients in tumour stages I and II were referred to surgery; patients in stage III-IV to postoperative radiotherapy (mean dose = 62.13 ± 7.74 Gy in 1.8–2 Gy/fraction). MVP expression was studied by immunohistochemistry in paraffin-embedded tumour tissue. Results: MVP expression was positive in 112 patients (85.5%) and no relation was found with clinic pathological variables. MVP overexpression (those tumours with moderate or strong expression of the protein) was related to insulin-like growth factor receptor-1 (IGF-1R) expression (P = 0.014). Tumour stage of the disease was the most important prognostic factor related to survival. Tumours overexpressing MVP and IGF-1R were strongly related to poor disease-free survival (P = 0.008, Exp(B) = 2.730, CI95% (1.302-5.724)) and cause-specific survival (P = 0.014, Exp(B) = 2.570, CI95% (1.215-5.437)) in patients achieving tumour stages III-IV, in multivariate analysis. Conclusions: MVP and IGF-1R expression were related in oral squamous cell carcinoma and conferred reduced long-term survival in patients suffering from advanced stages of the disease.en_US
dc.languageengen_US
dc.relation.ispartofRadiation Oncologyen_US
dc.sourceRadiation Oncology 2012en_US
dc.subject320101 Oncologíaen_US
dc.subject.otherMVPen_US
dc.subject.otherIGF-1Ren_US
dc.subject.otherOral carcinomaen_US
dc.subject.otherRadiotherapyen_US
dc.subject.otherPredictive factoren_US
dc.titleMVP expression in the prediction of clinical outcome of locally advanced oral squamous cell carcinoma patients treated with radiotherapyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1748-717X-7-147en_US
dc.identifier.scopus2-s2.0-84868693748-
dc.identifier.isi000311416700001-
dc.date.updated2012-11-09T07:46:18Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066en-
dc.rights.holderLuis Henríquez-Hernández et al.; licensee BioMed Central Ltd.-
dc.compliance.driver1-
dc.contributor.authorscopusid15829708200-
dc.contributor.authorscopusid56328294100-
dc.contributor.authorscopusid7202860969-
dc.contributor.authorscopusid7003855087-
dc.contributor.authorscopusid7004374085-
dc.identifier.eissn1748-717X-
dc.identifier.issue1-
dc.relation.volume7en_US
dc.investigacionCiencias de la Saluden_US
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess-
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess-
dc.type2Artículoen_US
dc.contributor.daisngid465624-
dc.contributor.daisngid3955607-
dc.contributor.daisngid4381521-
dc.contributor.daisngid802813-
dc.contributor.daisngid591076-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Henriquez-Hernandez, LA-
dc.contributor.wosstandardWOS:Moreno, M-
dc.contributor.wosstandardWOS:Rey, A-
dc.contributor.wosstandardWOS:Lloret, M-
dc.contributor.wosstandardWOS:Lara, PC-
dc.date.coverdateAgosto 2012en_US
dc.identifier.supplementhttp://dx.doi.org/10.1186/1748-717X-7-147-
dc.identifier.ulpgces
dc.description.sjr1,04
dc.description.jcr2,107
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNameLloret Sáez-Bravo, Marta-
crisitem.author.fullNameLara Jiménez, Pedro Carlos-
Colección:Artículos
miniatura
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