Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/77881
Title: Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial
Authors: Diáz-López, Andrés
Becerra-Tomás, Nerea
Ruiz, Verónica
Toledo, Estefania
Babio, Nancy
Corella, Dolores
Fitó, Montse
Romaguera, Dora
Vioque, Jesús
Alonso-Gómez, Ángel M.
Wärnberg, Julia
Martínez, J. Alfredo
Serra Majem, Luis 
Estruch, Ramon
Tinahones, Francisco J.
Lapetra, José
Pintó, Xavier
Tur, Josep A.
López-Miranda, José
Cano Ibañez, Naomi
Delgado-Rodríguez, Miguel
Matiá-Martín, Pilar
Daimiel, Lidia
De Paz, Jose Antonio
Vidal, Josep
Vázquez, Clotilde
Ruiz-Canela, Miguel
Bulló, Mònica
Sorlí, José V.
Goday, Albert
Fiol, Miquel
Garciá-De-La-Hera, Manoli
Tojal Sierra, Lucas
Pérez-Farinós, Napoleón
Zulet, Maria Ángeles
Sánchez Villegas, Almudena 
Sacanella, Emilio
Fernández-Garciá, José Carlos
Santos-Lozano, José Manuel
Gimenez-Gracia, Miquel
Del Mar Bibiloni, Maria
Diez-Espino, Javier
Ortega-Azorin, Carolina
Castañer, Olga
Morey, Marga
Torres-Collado, Laura
Sorto Sanchez, Carolina
Munõz, Miguel Ángel
Ros, Emilio
Martinez-Gonzalez, Miguel A.
Salas-Salvadó, Jordi
UNESCO Clasification: 32 Ciencias médicas
3206 Ciencias de la nutrición
Keywords: Dietary Intervention
Glomerular Filtration Rate
Kidney Function
Mediterranean Diet
Predimed-Plus, et al
Issue Date: 2021
Journal: American Journal of Nephrology 
Abstract: Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Methods: Randomized controlled "PREvención con DIeta MEDiterránea-Plus"(PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (EGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired EGFR (<60 mL/min/1.73 m2< >) and micro-to macroalbuminuria (UACR ≥30 mg/g), and reversion of moderately (45 to <60 mL/min/1.73 m2< >) to mildly impaired GFR (60 to <90 mL/min/1.73 m2< >) or micro-to macroalbuminuria. Results: After 1 year, EGFR declined by 0.66 and 1.25 mL/min/1.73 m<>2< > in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m2< >; 95% CI: 0.15-1.02). There were no between-group differences in mean UACR or micro-to macroalbuminuria changes. Moderately/severely impaired EGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44-0.82) and 92% higher (HR 1.92; 1.35-2.73), respectively, in the intervention group. Conclusions: The PREDIMED-Plus lifestyle intervention approach may preserve renal function and delay CKD progression in overweight/obese adults.
URI: http://hdl.handle.net/10553/77881
ISSN: 0250-8095
DOI: 10.1159/000513664
Source: American Journal of Nephrology [ISSN 0250-8095], (Febrero 2021)
Appears in Collections:Artículo preliminar
Show full item record

Page view(s)

67
checked on Sep 25, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.