Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/77718
Title: Amyloid-beta peptide and phosphorylated tau in the frontopolar cerebral cortex and in the cerebellum of toothed whales: aging versus hypoxia
Authors: Sacchini, Simona 
Diaz Delgado, Josue 
Espinosa De Los Monteros Y Zayas, Antonio 
Paz Sanchez, Yania 
Bernaldo De Quirós Miranda, Yara 
Sierra Pulpillo, Eva María 
Arbelo Hernández, Manuel Antonio 
Herráez Thomas, Pedro Manuel 
Fernández Rodríguez, Antonio Jesús 
UNESCO Clasification: 310907 Patología
3105 Peces y fauna silvestre
Keywords: Beaked whales Hypoxia
Beta amyloid
Phosphorylated tau
Toothed whales
Issue Date: 2020
Journal: Biology Open 
Abstract: Hypoxia could be a possible risk factor for neurodegenerative alterations in cetaceans’ brain. Among toothed whales, the beaked whales are particularly cryptic and routinely dive deeper than 1000 m for about 1 h in order to hunt squids and fishes. Samples of frontal cerebral and cerebellar cortex were collected from nine animals, representing six different species of the suborder Odontoceti. Immunohistochemical analysis employed anti-β-amyloid (Aβ) and anti-neurofibrillary tangle (NFT) antibodies. Six of nine (67%) animals showed positive immunolabeling for Aβ and/or NFT. The most striking findings were intranuclear Aβ immunopositivity in cerebral cortical neurons and NFT immunopositivity in cerebellar Purkinje neurons with granulovacuolar degeneration. Aβ plaques were also observed in one elderly animal. Herein, we present immunohistopathological findings classic of Alzheimer's and other neurodegenerative diseases in humans. Our findings could be linked to hypoxic phenomena, as they were more extensive in beaked whales. Despite their adaptations, cetaceans could be vulnerable to sustained and repetitive brain hypoxia.
URI: http://hdl.handle.net/10553/77718
ISSN: 2046-6390
DOI: 10.1242/bio.054734
Source: Biology Open [E2046-6390], 2020 9
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