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Title: Differences within Churra breed sheep in the early immune response to the infection by Teladorsagia circumcincta
Authors: Castilla-Gómez de Agüero, Verónica
González Pérez, Jorge Francisco 
Hernández Vega, Julia Natividad 
Valderas-García, Elora
Rojo Vázquez, Francisco A.
Arranz, Juan José
Gutiérrez-Gil, Beatriz
Martínez-Valladares, María
UNESCO Clasification: 240112 Parasitología animal
3104 Producción Animal
Keywords: IgA
Teladorsagia circumcincta
γδ T cells
Issue Date: 2021
Project: Control Sostenible de Parásitos en Ovinos Autóctonos Canarios 
Journal: Parasitology Research 
Abstract: This study describes early immunological mechanisms that underlie resistance to Teladorsagia circumcincta infection in adult Churra sheep. After a first experimental infection, 6 animals were classified as resistant (RG) and 6 as susceptible (SG) to T. circumcincta infection based on their cumulative faecal egg count (cFEC) at the end of the infection. RG showed higher IgA levels against somatic antigen of T. circumcincta fourth-larvae stage (L4) in serum at day 3 post-infection (pi) (p < 0.05) and close to significance at day 21 pi (p = 0.06). Moreover, a strong negative correlation between cFEC and specific IgA was only significant in RG at day 3 pi (r = - 0.870; p < 0.05), but absent in SG. At the end of this infection, sheep were treated with moxidectin and infected again 3 weeks later to be slaughtered at day 7 pi. At necropsy, the specific IgA levels in gastric mucosa were similar between groups; the absence differences at day 7 pi could be due to a previous increase in the IgA response, probably around day 3 pi, as described during the first infection. L4 burden, 68% lower in RG than in SG, was influenced by the specific IgA in gastric mucus and the number of γδ T cells. RG group showed a positive correlation between γδ T cells and eosinophils (r = 0.900; p = 0.037); however, this correlation was not found in SG. These results show that these two phenotypes show different early immune response pattern to T. circumcincta infection in Churra sheep.
ISSN: 0932-0113
DOI: 10.1007/s00436-020-06953-4
Source: Parasitology Research [0932-0113], v. 120(3), p. 1115-1120
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