W01.15. Interleukin inflammatory phenotypes in premature coronary atherosclerosis

Abstract

Patients with prematme coronary syndromes impose an enormous challenge to the long-term management of atherosclerosis. Though the inflammatory markers available are sensible, but lack specificity and are not permanent. We analysed the polymorphisms of two pleiotropic inflammatory media- tors, interleukin IL-8 (-251 A/T), and IL-6 (-174 G/C) promoters. PCR-SSP techniques rendered hyper, medium and hypoproductive phenotypes. We studied 393 patients (P), after a premature coronary syndrome were com- pared with 276 aged, healthy controls (C); both had similar AA-AT/TT and GG-GC/CC distributions. Results: Patients were 44 years old and controls 69; (p<0.000). With the exception of smoking (P81% vs. c52%; p<0.000), dyslipidemia (P63% vs. c37%; p<0.05), and family history of premature CHD (P37%vs. c14%; p<0.000) major risk factors were more prevalent among conU'ols. Patient study showed males were 4 years younger (F47 vs. M43; p<0.048). Gen- der diffelences included higher prevalence of diabetics (M74%vs. F25%; p<0.028), and smokers (M86%vs. F14%; p<0.000) among males. Multi- vessel disease related to dyslipidemia (86%; p<0.007), metabolic syndrome (35%; p<0.041) and hyperproductive IL-8 phenotype (75%; p<0.033) in males. Reculxence related to smoking (p<0.045), diabetes (p<0.05) and PCI (p<0.041). Hyperproductive IL-6 col~elated with metabolic syndrome (p<0.001) and IL-8 with multivessel disease (p<0.011). Hyperproductive IL-8 phenotype (p<0.010) explained 73.4% of recua~ence in a logistic regression model built with risk factors, gender, clinical features and both phenotypes. Conclusions: Despite an unusual model with a considerable age gap between patients and controls, patients had a higher prevalence of some major risk factors. Hyperproductive interleukin-8 phenotype is a suitable and permanent marker of rectuxence that may conU'ibute to characterise individual variability.