Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/76897
Title: Elastin variations implicating in vascular smooth muscle cells phenotype in human tortuous arteries
Authors: Ortiz, P. P.
Sarrat, R.
Daret, D.
Whyte, J.
Torres, A.
Daniel-Lamazière, J. M.
UNESCO Clasification: 240703 Morfología celular
Keywords: Elastin
Vascular Smooth Muscle Cells
Arterial Thickening
Arterial Tortuosity
Issue Date: 2000
Journal: Histology and Histopathology 
Abstract: The aim of the present work was to study the morphological implications between the elastin and the phenotypic expression of the vascular smooth muscle cells. For this purpose, sixty human tortuous arteries from different territories have been studied. We have measured the morphometric indexes Intimal Thickening Index and Elastolyse Index and they have been quantified with computer system analysis, image-colour corresponding to the orcein and Verhoeff reactions for detecting elastin and the alpha-actin in the smooth muscle cells. We compared both territorial arteries from the cranial and from abdominal origin. The elastin concentration was similar in both territories, but not its morphology according to its spatial distribution. We have observed a relationship between the elastin structural organisation from the media of arteries and of the internal elastic lamina in these territories and the variation of reactivity to the smooth muscle cr-actin as a marker of the phenotypic state.Our results confirm the hypothesis that elastin, besides intervening in the architecture of the arterial wall, is a factor implicated in the phenotypic variability of the smooth muscle cells and in the development and evolution of the intimal thickenings in human atherosclerosis.
URI: http://hdl.handle.net/10553/76897
ISSN: 0213-3911
DOI: 10.14670/HH-15.95
Source: Histology and Histopathology [ISSN 0213-3911], v. 15 (1), p. 95-100, (Enero 2000)
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