A kinetic study on the interaction between tazobactam (a penicillanic acid sulphone derivative) and active-site serine beta-lactamases

Título:	A kinetic study on the interaction between tazobactam (a penicillanic acid sulphone derivative) and active-site serine beta-lactamases
Autores/as:	Perilli, Mariagrazia Franceschini, Nicola Bonfiglio, Giovanni Segatore, Bernardetta Stefani, Stefania Nicoletti, Giuseppe Tavío Pérez, María Del Mar Bianchi, Ciro Zollo, Alessandro Amicosante, Gianfranco
Clasificación UNESCO:	3201 Ciencias clínicas
Palabras clave:	Beta-Lactamase Inhibitor Tazobactam Kinetics
Fecha de publicación:	1999
Publicación seriada:	Journal of Enzyme Inhibition
Resumen:	The interaction between tazobactam and several chromosome- and plasmid-encoded (TEM, SHV, PSE types) class A and C beta-lactamases was studied by spectrophotometry. Tazobactam behaved as a competitive inhibitor or inactivator able to restore in several cases the efficiency of piperacillin as st partner beta-lactam. A detailed kinetic analysis permitted measurement of the acylation efficiency for some cephalosporinases and broad-spectrum beta-lactamases; the presence of a turn-over of acyl-enzyme complex was also evaluated.
URI:	https://accedacris.ulpgc.es/handle/10553/76862
ISSN:	8755-5093
DOI:	10.1080/14756369909030337
Fuente:	Journal of Enzyme Inhibition [ISSN 8755-5093], v. 15 (1), p. 1-10, (1999)
Colección:	Artículos

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