Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/76862
Title: A kinetic study on the interaction between tazobactam (a penicillanic acid sulphone derivative) and active-site serine beta-lactamases
Authors: Perilli, Mariagrazia
Franceschini, Nicola
Bonfiglio, Giovanni
Segatore, Bernardetta
Stefani, Stefania
Nicoletti, Giuseppe
Tavío Pérez, María Del Mar 
Bianchi, Ciro
Zollo, Alessandro
Amicosante, Gianfranco
UNESCO Clasification: 3201 Ciencias clínicas
Keywords: Beta-Lactamase
Inhibitor
Tazobactam
Kinetics
Issue Date: 1999
Journal: Journal of Enzyme Inhibition 
Abstract: The interaction between tazobactam and several chromosome- and plasmid-encoded (TEM, SHV, PSE types) class A and C beta-lactamases was studied by spectrophotometry. Tazobactam behaved as a competitive inhibitor or inactivator able to restore in several cases the efficiency of piperacillin as st partner beta-lactam. A detailed kinetic analysis permitted measurement of the acylation efficiency for some cephalosporinases and broad-spectrum beta-lactamases; the presence of a turn-over of acyl-enzyme complex was also evaluated.
URI: http://hdl.handle.net/10553/76862
ISSN: 8755-5093
DOI: 10.1080/14756369909030337
Source: Journal of Enzyme Inhibition [ISSN 8755-5093], v. 15 (1), p. 1-10, (1999)
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