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http://hdl.handle.net/10553/76862
| Title: | A kinetic study on the interaction between tazobactam (a penicillanic acid sulphone derivative) and active-site serine beta-lactamases | Authors: | Perilli, Mariagrazia Franceschini, Nicola Bonfiglio, Giovanni Segatore, Bernardetta Stefani, Stefania Nicoletti, Giuseppe Tavío Pérez, María Del Mar Bianchi, Ciro Zollo, Alessandro Amicosante, Gianfranco |
UNESCO Clasification: | 3201 Ciencias clínicas | Keywords: | Beta-Lactamase Inhibitor Tazobactam Kinetics |
Issue Date: | 1999 | Journal: | Journal of Enzyme Inhibition | Abstract: | The interaction between tazobactam and several chromosome- and plasmid-encoded (TEM, SHV, PSE types) class A and C beta-lactamases was studied by spectrophotometry. Tazobactam behaved as a competitive inhibitor or inactivator able to restore in several cases the efficiency of piperacillin as st partner beta-lactam. A detailed kinetic analysis permitted measurement of the acylation efficiency for some cephalosporinases and broad-spectrum beta-lactamases; the presence of a turn-over of acyl-enzyme complex was also evaluated. | URI: | http://hdl.handle.net/10553/76862 | ISSN: | 8755-5093 | DOI: | 10.1080/14756369909030337 | Source: | Journal of Enzyme Inhibition [ISSN 8755-5093], v. 15 (1), p. 1-10, (1999) |
| Appears in Collections: | Artículos |
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