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Title: High Plasma Glutamate and a Low Glutamine-to-Glutamate Ratio Are Associated with Increased Risk of Heart Failure but Not Atrial Fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study
Authors: Papandreou, Christopher
Hernández-Alonso, Pablo
Bulló, Mònica
Ruiz-Canela, Miguel
Li, Jun
Guasch-Ferré, Marta
Toledo, Estefanía
Clish, Clary
Corella, Dolores
Estruch, Ramon
Cofán, Montserrat
Fitó, Montserrat
Razquin, Cristina
Arós, Fernando
Fiol, Miquel
Santos-Lozano, José M.
Serra Majem, Luis 
Liang, Liming
Martínez-González, Miguel A.
Hu, Frank B.
Salas-Salvadó, Jordi
UNESCO Clasification: 32 Ciencias médicas
3206 Ciencias de la nutrición
Keywords: Atrial Fibrillation
Heart Failure
Issue Date: 2020
Journal: Journal of Nutrition 
Abstract: BACKGROUND: Although the association between glutamate and glutamine in relation to cardiometabolic disorders has been evaluated, the role of these metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remains unknown. OBJECTIVES: We examined associations of glutamate, glutamine, and the glutamine-to-glutamate ratio with AF and HF incidence in a Mediterranean population at high cardiovascular disease (CVD) risk. METHODS: The present study used 2 nested case-control studies within the PREDIMED (Prevención con Dieta Mediterránea) study. During ∼10 y of follow-up, there were 509 AF incident cases matched to 618 controls and 326 HF incident cases matched to 426 controls. Plasma concentrations of glutamate and glutamine were semiquantitatively profiled with LC-tandem MS. ORs were estimated with multivariable conditional logistic regression models. RESULTS: In fully adjusted models, per 1-SD increment, glutamate was associated with a 29% (95% CI: 1.08, 1.54) increased risk of HF and glutamine-to-glutamate ratio with a 20% (95% CI: 0.67, 0.94) decreased risk. Glutamine-to-glutamate ratio was also inversely associated with HF risk (OR per 1-SD increment: 0.80; 95% CI: 0.67, 0.94) when comparing extreme quartiles. Higher glutamate concentrations were associated with a worse cardiometabolic risk profile, whereas a higher glutamine-to-glutamate ratio was associated with a better cardiometabolic risk profile. No associations between the concentrations of these metabolites and AF were observed. CONCLUSIONS: Our findings suggest that high plasma glutamate concentrations possibly resulting from alterations in the glutamate-glutamine cycle may contribute to the development of HF in Mediterranean individuals at high CVD risk.
ISSN: 1541-6100
DOI: 10.1093/jn/nxaa273
Source: The Journal of nutrition [EISSN 1541-6100], v. 150 (11), p. 2882-2889, (Noviembre 2020)
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