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Title: Application of an ELISA test using Schistosoma bovis adult worm antigens in travellers and immigrants from a schistosomiasis endemic area and its correlation with clinical findings
Authors: Pardo, Javier
Perez Arellano, Jose Luis 
López-Vélez, Rogelio
Carranza Rodríguez, Cristina 
Cordero, Miguel
Muro, Antonio
UNESCO Clasification: 32 Ciencias médicas
3202 Epidemologia
Keywords: Linked-Immunosorbent-Assay
Imported Schistosomiasis
Serodiagnosis, et al
Issue Date: 2007
Journal: Scandinavian Journal of Infectious Diseases 
Abstract: We have recently evaluated an ELISA for the diagnosis of human schistosomiasis using S. bovis adult worm antigens (AWA Sb), showing a sensitivity of 94% and a specificity of 97% for patients diagnosed by egg detection. Nevertheless, the comparison of this AWA Sb ELISA with direct parasitological findings as the gold standard could introduce a selection bias, due to the well-known lack of sensitivity of direct methods in the detection of acute schistosomiasis and of low burden infections. The objective of the present work is to compare it with parasitological methods and commercial indirect haemagglutination test using S. mansoni antigens (WA Sm IHA) in 254 immigrants and travellers with different clinical settings; in addition, to find specific bands in the EITB of different phases of schistosomiasis. The AWA Sb ELISA showed 72% of seropositivity in patients with Katayama fever, while patients with eosinophilia and genito-urinary complaints showed 27% and 93%, respectively. The diagnosis yield was globally higher than direct egg detection or WA Sm IHA test with regard to the clinical setting. Finally, the utilization of EITB with S. bovis AWA permits the confirmation of diagnosis in chronic and acute phases of the disease.
ISSN: 0036-5548
DOI: 10.1080/00365540601105806
Source: Scandinavian Journal of Infectious Diseases [ISSN 0036-5548], v. 39 (5), p. 435-440, (2007)
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