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Title: Aspirin, sodium benzoate and sodium salicylate reverse resistance to colistin in Enterobacteriaceae and Pseudomonas aeruginosa
Authors: Malla, Cristina F.
Mireles, Natalia A.
Ramírez Corbera, Ana Sofía 
Poveda Guerrero, José Bismarck 
Tavío Pérez, María Del Mar 
UNESCO Clasification: 32 Ciencias médicas
3209 Farmacología
3207 Patología
Keywords: Aspirin
Pseudomonas aeruginosa
Sodium benzoate
Issue Date: 2020
Journal: Journal of Antimicrobial Chemotherapy 
Abstract: BACKGROUND: MDR bacterial infections are currently a serious problem for clinicians worldwide. Klebsiella pneumoniae and Enterobacter spp., among Enterobacteriaceae, and Pseudomonas aeruginosa, are part of the group of ESCAPE pathogens or bacteria that 'escape' from common antibacterial treatments. The lack of effectiveness of the first common line of antibiotics has led to the search for new therapies based on older antibiotics, such as colistin. OBJECTIVES: We searched for new enhancers of the action of colistin against MDR Gram-negative bacteria that can be easily applicable to clinical treatments. METHODS: Colistin MICs were determined alone and with the protonophores CCCP, sodium benzoate, sodium salicylate and aspirin using the broth microdilution method and FIC indexes were calculated to assess synergy between colistin and each chemical. Time-kill assays of colistin with and without protonophores were performed to determine the bactericidal action of combinations of colistin with protonophores. Likewise, the effect of sucrose, l-arginine and l-glutamic acid on the MICs of colistin alone and combined with each protonophore was assessed. RESULTS: It was found that sodium benzoate, sodium salicylate and aspirin, at concentrations allowed for human and animal use, partially or totally reversed resistance to colistin in P. aeruginosa and highly resistant enterobacterial strains. The mechanism of action could be related to their negative charge at a physiological pH along with their lipid-soluble character. CONCLUSIONS: Sodium benzoate, sodium salicylate and aspirin are good enhancers to use in antibiotic therapies that include colistin.
ISSN: 1460-2091
DOI: 10.1093/jac/dkaa371
Source: Journal of antimicrobial chemotherapy [1460-2091], v. 75 (12), p. 3568-3575, (Diciembre 2020)
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