Identificador persistente para citar o vincular este elemento:
https://accedacris.ulpgc.es/handle/10553/75103
| Título: | Preparation of 2,2-dimethylchroman-4-ones from 5-alkyl-substituted resorcinols: microwave-assisted synthesis and theoretical calculations |
| Autores/as: | Morales, Paula Azofra Mesa, Luis Miguel Cumella, José Hernandez-Folgado, Laura Roldán, María Alkorta, Ibon Jagerovic, Nadine |
| Coordinadores/as, Directores/as o Editores/as: | Iglesias-Arteaga, Martin A. |
| Clasificación UNESCO: | 2307 Química física |
| Palabras clave: | Chromanone DFT calculation Friedel-Crafts reactions Cannabinoids |
| Fecha de publicación: | 2014 |
| Publicación seriada: | Arkivoc |
| Resumen: | The influence of different 5-alkyl-substituted resorcinols on the formation of 2,2-dimethylchroman-4-ones is examined experimentally and theoretically. Structures are fully assigned by means of experimental and theoretical 13C and 1H NMR chemical shifts. Based on experimental and theoretical calculations of Friedel-Crafts acylation, it is possible to explain the formation of 2,2-dimethyl-5-hydroxychroman-4-ones and/or 2,2-dimethyl-7-hydroxychroman-4-ones. Evaluation of their biological activity as cannabinoid receptor ligands is also reported. |
| URI: | https://accedacris.ulpgc.es/handle/10553/75103 |
| ISSN: | 1551-7012 |
| DOI: | 10.3998/ark.5550190.p008.246 |
| Fuente: | Arkivoc [ISSN 1551-7012], v. 2, p. 319-332 |
| Colección: | Artículos |
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