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Title: Manganese‐Catalyzed Multicomponent Synthesis of Pyrroles through Acceptorless Dehydrogenation Hydrogen Autotransfer Catalysis: Experiment and Computation
Authors: Borghs, Jannik C.
Azofra Mesa, Luis Miguel 
Biberger, Tobias
Linnenberg, Oliver
Cavallo, Luigi
Rueping, Magnus
El‐Sepelgy, Osama
UNESCO Clasification: 221001 Catálisis
Issue Date: 2019
Journal: ChemSusChem 
Abstract: A new base metal catalyzed sustainable multicomponent synthesis of pyrroles from readily available substrates is reported. The developed protocol utilizes an air‐ and moisture‐stable catalyst system and enables the replacement of themutagenic α‐haloketones with readily abundant 1,2‐diols. Moreover, the presented method is catalytic in base and the sole byproducts of this transformation are water and hydrogen gas. Experimental and computational mechanistic studies indicate that the reaction takes place through a combined acceptorless dehydrogenation hydrogen autotransfer methodology.
ISSN: 1864-5631
DOI: 10.1002/cssc.201802416
Source: ChemSusChem [ISSN 1864-5631], v. 12, p. 3083-3088, Special Issue:Sustainable Organic Synthesis (Julio 2019)
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