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Title: The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries)
Authors: Sakthivel, Dhanasekaran
Preston, Sarah
Gasser, Robin B.
Costa, Tatiana P.Soares da
Hernández Vega, Julia Natividad 
Shahine, Adam
Shakif-Azam, M. D.
Lock, Peter
Rossjohn, Jamie
Perugini, Matthew A.
González Pérez, Jorge Francisco 
Meeusen, Els
Piedrafita, David 
Beddoe, Travis
UNESCO Clasification: 310907 Patología
240112 Parasitología animal
Keywords: Antimicrobial responses
Issue Date: 2020
Journal: Communications Biology
Abstract: Galectins are a family of glycan-binding molecules with a characteristic affinity for ß-D-glycosides that mediate a variety of important cellular functions, including immune and inflammatory responses. Galectin-11 (LGALS-11) has been recently identified as a mediator induced specifically in animals against gastrointestinal nematodes and can interfere with parasite growth and development. Here, we report that at least two natural genetic variants of LGALS-11 exist in sheep, and demonstrate fundamental differences in anti-parasitic activity, correlated with their ability to dimerise. This study improves our understanding of the role of galectins in the host immune and inflammatory responses against parasitic nematodes and provides a basis for genetic studies toward selective breeding of animals for resistance to parasites.
ISSN: 2399-3642
DOI: 10.1038/s42003-020-01179-7
Source: Communications Biology [EISSN 2399-3642], v. 3 (1), (Diciembre 2020)
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