Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/74407
Title: Primary frontal sinus squamous cell carcinoma in three dogs treated with piroxicam combined with carboplatin or toceranib
Authors: de Vos, J.
Ramos Vega, Sara
Noorman, E.
de Vos, P.
UNESCO Clasification: 310907 Patología
320713 Oncología
Keywords: Para-Nasal Sinuses
Radiation-Therapy
Paranasal Sinuses
Neck-Cancer
Head
Cavity
Tumors
Recurrent
Carboplatin
Dog
Frontal Sinus
Piroxicam
Squamous Cell Carcinoma
Toceranib
Issue Date: 2012
Journal: Veterinary and Comparative Oncology 
Abstract: In human medicine, primary frontal sinus squamous cell carcinoma (pFS-SCC) is not frequently reported. In veterinary medicine, frontal sinus SCC is exclusively described as an extension of nasal cavity SCC. To our knowledge, this is the first publication concerning canine pFS-SCC, diagnosed using histology or cytology and medical imaging, in three dogs. The tumours extended into the orbit or brain cavity, without nasal involvement. Treatment was initiated with piroxicamcarboplatin. Prolongation of carboplatin delivery with a low dose intensity was performed on dogs with a favourable initial response. Dog 1 achieved a complete remission (CR), but was euthanized 344 days after start of therapy. Dog 2, still alive 3 years after start of therapy and in CR, received 14 carboplatin deliveries. In dog 3, after changing the treatment protocol into piroxicamtoceranib, a significant tumour reduction occurred, but the dog was euthanized after 195 days because of a relapse.
URI: http://hdl.handle.net/10553/74407
ISSN: 1476-5810
DOI: 10.1111/j.1476-5829.2011.00292.x
Source: Veterinary And Comparative Oncology [ISSN 1476-5810], v. 10 (3), p. 206-213, (Septiembre 2012)
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