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Title: Longitudinal overgrowth of bone after osteotomy in young rats: Influence of bone stability
Authors: Garcés, G. L. 
García Castellano, J. M.
Nogales, J.
UNESCO Clasification: 310909 Fisiología)
321304 Cirugía de huesos
Keywords: Bone Growth
Issue Date: 1997
Journal: Calcified Tissue International 
Abstract: One hundred and five 5-week-old male rats were used to study the influence of the stability of an osteotomy on longitudinal overgrowth of the bone. In 45 rats (Group 1) a transverse diaphyseal osteotomy of the right tibia Mras made; the left tibia was left untreated. In the second 45 rats (Group 2) the right tibia was osteotomized after applying an external fixator; the left tibia underwent a sham operation without osteotomy. Fifteen further rats (Group 3) were used as a nonoperated control group. After being measured at different periods up to 20 weeks, the osteotomized tibiae of the Group 1 (unstable) were 16-25% longer than those of their nontreated limbs (P < 0.001). The osteotomized tibiae of the Group 2 (stable) were 6-11% longer than those of the sham-operated opposite limbs (P < 0.001). The osteotomized and unstable tibiae were 9-17% longer than the osteotomized and stable tibiae (P < 0.001) throughout the whole study. Although several factors have been considered to be responsible for longitudinal bone overgrowth after fracture in young animals, this work suggests that bent's stability plays a decisive role in the final outcome.
ISSN: 0171-967X
DOI: 10.1007/s002239900249
Source: Calcified Tissue International [ISSN 0171-967X], v. 60 (4), p. 391-393, (Abril 1997)
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